CAS: 82626-01-5; 2-[6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridin-3-Yl]-N,N-Dipropylacetamide

上下游产品

6-氯-2-(4-氯苯基)咪唑并[1,2-A]吡啶-3-乙酸 2-(6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridin-3-yl)Acetic Acid 82626-74-2
6-氯-2-(4-氯苯基)咪唑并[1,2-A]吡啶-3-乙腈 2-(6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridin-3-yl)Acetonitrile 82626-72-0
Ethyl 2-(6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridin-3-yl)Acetate 193979-48-5
6-氯-2-(4-氯苯基)咪唑并[1,2-A]-吡啶-3-甲醛 6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridine-3-Carbaldehyde 351227-28-6
6-氯-2-(4-氯苯基)咪唑并[1,2-A]吡啶 6-Chloro-2-(4-Chlorophenyl)Imidazo[1,2-A]Pyridine 88964-99-2

📜3-(4-氯苯甲酰)丙酸置于溴,2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉,三乙胺体系中,用 四氢呋喃,四氯化碳,正丁醇 作为反应溶剂,化学反应 6.0H,反应生成 阿尔吡登
参考文献:2-苯基咪唑并[1,2-α]吡啶衍生物的合成及其对中心和外围苯并二氮杂receptor受体的结合亲和力.针对外围类型的一系列新的高亲和力和选择性配体.
标题:2-苯基咪唑并[1,2-α]吡啶衍生物的合成及其对中心和外围苯并二氮杂receptor受体的结合亲和力.针对外围类型的一系列新的高亲和力和选择性配体.
摘要:若干个6-取代或6,8-二取代的2-苯基咪唑并[1,2-α-吡啶-3-羧酸烷基酯5A-H,-乙酸酯5I-S,6A-G和-丙酸酯5T,6H和n,N-二烷基-2-苯基咪唑并[1,2-α吡啶-3-甲酰胺7A-D,-乙酰胺7E-T或-丙酰胺7U是按照新的合成方法制备的,并且它们对两个环的亲和力(cbr)和外围(pbr)苯并二氮杂receptor受体进行了评估.酯系列化合物对两种受体类型均显示出低亲和力.相反,大多数n,N-二烷基(2-苯基咪唑并[1,2-α吡啶基-3-基]乙酰胺)7E-T对cbr或pbr具有高亲和性和选择性,这取决于c(c 6)-和/或杂环系统上的c(8).特别是,6-取代的化合物7F-N的ic50值之比(ic50(cbr)/ Ic50(pbr))为0.32(7M)至232(7K),而6,8-二取代的化合物7O-T大于pbr的选择性是cbr的1000倍.检查了几种不同的苯二氮卓类
DOI:10.1021/jm970112+

专利信息

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-11485721-B2
优先权日:2017-11-21
标 题:Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses
发明人：KLOSS FLORIAN; NEUWIRTH TONI; HAENSCH VEIT; HERTWECK CHRISTIAN
权利人:LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST HKI; LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST
摘要:The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:WO-2023141114-A2
优先权日:2022-01-18
标 题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

专利号:AU-2023208727-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

专利号:ES-2379919-B1
优先权日:2010-10-06
标 题 :SYNTHESIS OF BICYCLIC PIRIDONAS CONTAINING THE HIDEROCYCLIC SYSTEM OF IMIDAZOL (1,2-a) PIRIDINE, FROM 2-AMINO-6- (PROP-2-IN-1-IL AMINO) PIRIDINES.