CAS: 72607-53-5; N-(3-Aminopropyl)Methacrylamide Hydrochloride

相似化合物

76259-32-0 5205-93-6 86742-39-4

📜Tert-Butyl (3-Methacrylamidopropyl)Carbamate置于盐酸体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,化学反应 16.0H,以96%的收率获得产物n-(3-氨基丙基)甲基丙烯酸盐 盐酸盐
参考文献:Us2014/271461
标题:Us2014/271461

专利信息

专利号:US-6410643-B1
优先权日:2000-03-09
标题 :Solid phase synthesis method and reagent
发明人：SWANSON MELVIN J
权利人:SURMODICS INC
摘要:A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.

专利号:US-2008234391-A1
优先权日:2007-03-21
标题 :Synthesis of Reversible Shell Crosslinked Nanostructures
发明人：MCCORMICK CHARLES L; LOKITZ BRAD S; LI YUTING
权利人:MCCORMICK CHARLES L; LOKITZ BRAD S; LI YUTING
摘要:In one aspect, the present invention is directed to a thermally responsive AB diblock copolymer prepared by RAFT polymerization wherein the diblock copolymer comprises poly(N-(3-aminopropyl)methacrylamide hydrochloride)-block-(N-isopropylacrylamide). Nanostructures of the thermally responsive diblock copolymer are formed by molecularly dissolving the diblock copolymer in aqueous solution at room temperature; and increasing the solution temperature to form nanostructures, for example vesicles or micelles. The first RAFT polymerization of an unprotected amino acid based monomer directly in water is also disclosed. The present invention also provides a method of forming shell cross-linked vesicles by adding a RAFT synthesized anionic homopolymer to a solution of the thermally responsive diblock copolymer. A method of forming interpolyelectrolyte complexed micelles or vesicles is also disclosed, the method comprising preparing by sequential aqueous RAFT polymerization a block copolymer comprised of N,N,-dimethyl acrylamide (DMA), N-acryloyl alanine (AAL) and N-isopropyl acrylamide (NIPAM); dissolving the block copolymers into aqueous solution; raising the solution temperature above the lower critical solution temperature of the NIPAM block; allowing the micelle solution to equilibrate; adjusting the pH of the solution to about 5; adding a cationic polymer to the solution; and stirring the solution. The reaction is readily reversed by the addition of a salt solution. In another aspect of the invention a reversible shell cross-linked micelle of a triblock copolymer cross-linked with cystamine is disclosed where a cleaving agent can be added to cleave the micelles. The reaction can be reversed with the addition of tris(2-carboxyethyl)phosphine or dithiothreitol.

专利号:US-9006345-B2
优先权日:2011-03-25
标题 :Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
发明人：LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J
权利人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J; UNIV COLUMBIA
摘要:In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.

专利号:US-7989505-B2
优先权日:2005-09-23
标题:Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture
发明人：HU ZHIBING; ZHOU JUN; CAI TONG; TANG SHIJUN; MARQUEZ MANUEL
权利人:UNIV NORTH TEXAS
摘要:The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAMâ€?)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.

专利号:US-2023096993-A1
优先权日:2020-01-13
标 题 :Synthesis of cross-linked spherical polycationic bead adsorbents for heparin recovery
发明人：ABBASPOURRAD ALIREZA; ENAYATINOOK MOJTABA; ABDOLMALEKI MAHMOOD KARIMI
权利人:UNIV CORNELL
摘要:The present application relates to a polymerizable composition comprising: (a) a first monomer of Formula (I): (I) wherein R as described herein and (b) a second monomer of Formula (II): (II) The present application also relates to one or more adsorbent beads produced by polymerizing the polymerizable composition and to a method for heparin recovery using the adsorbent beads.

专利号:US-9913926-B2
优先权日:2008-01-24
标题 :Adhesive complex coacervates and method of making and using thereof
发明人：STEWART RUSSELL J; SHAO HUI
权利人:STEWART RUSSELL J; SHAO HUI; UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.