CAS: 6914-76-7; 1-Methylcyclopropane-1-Carboxylic Acid

相似化合物

2746-14-7 71441-76-4 933755-97-6

上下游产品

methyl 1-methylcyclopropanecarboxylate carbon dioxide 2-methylallylmagnesium chloride 1-(1-methylcyclopropyl)ethanone 1-methylcyclopropanecarboxamide 1-(1-methylcyclopropyl)ethanone 1-methylcyclopropanecarbonyl chloride 1-methylcyclopropylamine hydr°Chloride

Benzyl 2,2-Dichloro-1-Methylcyclopropylcarboxylate置于sodium,盐酸体系中,用 四氢呋喃,乙醇,水,甲苯 作为反应溶剂,化学反应 1.0H,以93.3%的收率获得产物1-甲基环丙烷-1-羧酸
参考文献:一种制备1-甲基环丙基甲酸的方法
标题:一种制备1-甲基环丙基甲酸的方法
摘要:本发明公开了一种制备1-甲基环丙基甲酸的方法,属于精细化工和医药中间体领域.本发明以甲基丙烯酸(酯或盐),或甲基丙烯腈,或甲基丙烯酰胺为原料,先与三卤化物在碱存在下发生环丙基化反应,反应生成2,2-偕卤化物(Iii),2,2-偕卤化物(Iii)再与金属钠反应脱去环上卤原子反应生成甲基环丙酸盐或甲基环丙基腈或甲基环丙基酰胺(II).甲基环丙基甲酸盐经酸化,得到1-甲基环丙基甲酸(I).甲基环丙基腈和甲基环丙基酰胺经碱性水解,再酸化得到1-甲基环丙基甲酸(I).本发明所有原料易得,反应条件温和,操作方便,成本低,所得产品纯度高,是一种可行的制备方法.

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries