CAS: 62014-87-3; (E)-1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Hydroxyphenyl)Prop-2-En-1-One
该化合物是因可能有药理特性而闻名的甲状腺素生物活性叶素化合物,它具有明显的抗氧化剂和抗炎活动,成为生物医学研究的热点.从结构上讲,它具有一个铬骨柱,有助于它捕食自由基体和调节细胞信号路径的能力.初步研究表明它对于减轻氧化性压力和炎症相关条件的效用.Helichrysetin的稳定性和溶解性简介进一步支持其适用于制剂开发.进行中的研究探索其行动机制,特别是慢性疾病方面的行动机制.该化合物是治疗和营养病环境进一步调查的一个大有希望的候选者.
- 英文名称(E)-1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Hydroxyphenyl)Prop-2-En-1-One
- 中文名称4,2',4'-三羟基-6'-甲氧基查耳酮
- IUPAC名称(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
- 其它别名Helichrysetin; 1-(2,4-Dihydroxy-6-Methoxy-Phenyl)-3-(4-Hydroxy-Phenyl)-Propenone; (E)-1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Hydroxyphenyl)Prop-2-En-1-One; 2-Propen-1-One, 1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Hydroxyphenyl)-, (2E)-; (2E)-1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Hydroxyphenyl)-2-Propen-1-One; Heliocentric; Inhibitor,Apoptosis,Growth,Dcis,Helichrysetin,Inhibit,Cell,Cycle,Id2,Anticancer; 2',4,4'-Trihydroxy 6'-Methoxychalcone
- CAS编号62014-87-3
- MFCD编号:MFCD12546716
- FDA UNII编号:MJ0KMG7AW4
- 分子式:C16H14O5分子量:286.28
- 产品CID: 1602288
- 产品分类天然产物 → 查尔酮类化合物
物理性质
MSDS等安全信息
上下游产品
CAS号1070781-94-0 (2E)-1-[2-metho... | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号3420-72-2 黄卡瓦胡椒素A; 2'- 羟基... | CAS号37308-75-1 卡瓦胡椒素C合成工艺路线路线简述
📜在 对甲苯磺酸体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 蜡菊亭; 4,2',4'-三羟基-6'-甲氧基查耳酮
参考文献:Synthesis And Structural Reassignment Of (+)-Epicalyxin F
标题:Synthesis And Structural Reassignment Of (+)-Epicalyxin F
摘要:We Have Established The Structure Of (+)-Epicalyxin F Through Chemical Synthesis. An Acid-Promoted Rearrangement Of Synthetic Benzopyran 6 Led To The Identification Of The Natural Product As (3S,5S,7R)-Epicalyxin F (22). Comparison With NMR Spectra And Optical Rotation Of The Natural Product Confirms Our Assignment,And The Reassigned Structure Is Compatible With The Proposed Biosynthetic Pathway.
DOI:10.1021/ol702200T
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9061984-B2
优先权日:2008-08-15
标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
发明人：HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
专利号:ES-2955412-T3
优先权日:2021-05-07
标题:A method of xanthohumol synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Phan CW, Sabaratnam V, Yong WK, Abd Malek SN. The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells. Nat Prod Res. 2017 May
25:1-5. doi: 10.1080/14786419.2017.1331226. [Epub ahead of print] doi: 10.1021/acs.jafc.5b01858. Epub 2015 Jul 10. doi: 10.1016/j.jep.2015.04.047. Epub 2015 May 7. doi: 10.1155/2013/857257. Epub 2013 Mar 3.
5: Vogel S, Barbic M, Jürgenliemk G, Heilmann J. Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect. Eur J Med Chem. 2010 Jun;45(6):2206-13. doi: 10.1016/j.ejmech.2010.01.060. Epub 2010 Jan 29. doi: 10.1016/j.bmc.2008.02.079. Epub 2008 Feb 29. Epub 2005 Nov 2.
合成参考文献
参考文献:10.1016/s0031-9422(97)00606-7|10.1016/s0031-9422(98)80083-6
摘要:Ngo K, Brown GD. Stilbenes, monoterpenes, diarylheptanoids, labdanes and chalcones from Alpinia katsumadai. Phytochemistry. 1998 Mar;47(6):1117–23. doi: 10.1016/s0031-9422(98)80083-6.
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