CAS: 5682-25-7; (2S,3R,4S,5R)-2-(6-Amino-9H-Purin-9-yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

上下游产品

腺苷 Adenosine 58-61-7
(2S,3R,4S,5R)-2-(6-Chloropurin-9-yl)-5-(Hydroxymethyl)Oxolane-3,4-Diol

📜甲基-Beta-D-呋喃核糖苷置于吡啶,盐酸,二苯并-18-冠醚-6,氨,Potassium Iodide体系中,用 1,4-二氧六环,甲醇,甲苯,乙腈 作为反应溶剂,化学反应 1.0H,反应生成 Alpha-腺苷
参考文献:2'-脱氧核糖核苷的区域特异性合成的改进程序
标题:2'-脱氧核糖核苷的区域特异性合成的改进程序
摘要:通过用ki-二苯并-18-冠-6 Ptc催化未保护的甲硅烷基化的嘌呤和嘧啶与适当的易得的2-脱氧核糖呋喃糖基或吡喃糖基糖衍生物之间的缩合,可以高特异性合成2'-脱氧核糖核苷.
DOI:10.1016/s0040-4039(00)97641-X

专利信息

专利号:WO-2020128469-A1
优先权日:2018-12-19
标 题 :Synthesis of 8-chloroadenosine derivatives including nuc-9701
发明人：GARLAPATI RAMESH; KOTALA MANI BUSHAN; EVANS JAMES; KENNOVIN GORDON
权利人:NuCana plc
摘要:The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chloroadenosine.

专利号:US-9738679-B2
优先权日:2013-03-15
标 题:Methods of synthesizing substituted purine compounds
发明人：OLHAVA EDWARD JAMES
权利人:EPIZYME INC
摘要:The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also provides novel crystalline forms of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof (Form A, Form B, and Form C), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.

专利号:US-2022402962-A1
优先权日:2017-06-14
标题 :Synthesis of phosphate derivatives

专利号:US-2020181186-A1
优先权日:2017-06-14
标 题:Synthesis of phosphate derivatives

专利号:US-2020181190-A1
优先权日:2017-06-14
标 题 :Synthesis of 3'-deoxyadenosine-5'-o-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738)

专利号:EP-0360626-A1
优先权日:1988-09-20
标 题:Process for the synthesis of alpha-oligoribonucleotides, and components useful in the process