CAS: 1860875-51-9; 2-(4-Chlorophenyl)-N-((2-(2,6-Dioxopiperidin-3-yl)-1-Oxoisoindolin-5-yl)Methyl)-2,2-Difluoroacetamide

上下游产品

3-(5-(Aminomethyl)-1-Oxoisoindolin-2-yl)Piperidine-2,6-Dione 1010100-28-3
2-(2,6-Dioxopiperidin-3-yl)-1-Oxoisoindoline-5-Carbonitrile 1010100-27-2

📜4-溴-2-甲基苯甲酸置于n-甲基吗啉,1,1'-双(二苯基膦)二茂铁,Tris-(Dibenzylideneacetone)Dipalladium(0),N-溴代丁二酰亚胺(Nbs),偶氮二异丁腈,硫酸,Palladium 10% On Activated Carbon,Zinc Diacetate,氢气,1-丙基磷酸酐,三乙胺体系中,用 丙醇,水,N,N-二甲基甲酰胺,乙腈 用作溶剂,20.0~120.0 °C,310.27 Kpa 条件下,反应 81.0H,反应生成化合物cereblonmodulator1
参考文献:Processes For Preparing 2-(4-Chlorophenyl)-N-((2-(2,6-Dioxopiperidin-3-yl)-1-Oxoisoindolin-5-yl)Methyl)-2,2-Difluoroacetamide
标题:Processes For Preparing 2-(4-Chlorophenyl)-N-((2-(2,6-Dioxopiperidin-3-yl)-1-Oxoisoindolin-5-yl)Methyl)-2,2-Difluoroacetamide
摘要:本文提供了制备2-(4-氯苯基)-N-((2-(2,6-二氧杂环己-3-基)-1-氧代异吲哚-5-基)甲基)-2,2-二氟乙酰胺的过程.

专利信息

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof