CAS: 18496-54-3; 4-Phenylbutanoylchloride

该化合物是一种有机化合物,其功能组分,包括苯环和丙基氯化物,其特点是无色的黄色液体,其发光的气味一般是粉色的黄色液体,表明其反应性.乙基氯的出现使它成为一种强大的电极,使它可以随时参与核生殖性乙基替代反应.该化合物在二氯甲烷和乙醚等有机溶剂中溶解,但由于其水分偏激苯环,一般在水中无法溶解.重要的是要谨慎处理苯丁基氯化物,因为它可以是腐蚀性的,并可能对皮肤,眼睛和呼吸系统造成刺激.在合成有机化学中,它经常被用作各种药品,农业化学品和其他精密化学品的生产中的中间体.在冷干的地方适当储存水分解对保持其稳定性和再活性至关重要.

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上下游产品

4-Phenylbutyric acid styrylacetic acid oxalyl dichloride 4-phenyl-butan-1-ol 1-morpholino-4-phenylbutan-1-one 1-(2-thienyl)-4-phenylbutan-1-one 4-phenyl-butyric acid-[2]pyridylamide 4-phenyl-butyric acid-(1-phenyl-2-pyrrolidino-ethyl ester); hydr°Chloride

合成工艺路线路线简述

  • 合成目标产物 4-Phenylbutyryl Chloride 主要起始原料 Oxalyl Chloride And 4-Phenylbutyric Acid
  • (文献来源)合成步骤主要原料 Oxalyl Chloride 和 4-Phenylbutyric Acid
📜4-苯基-3-丁烯酸置于sodium Amalgam,五氯化磷体系中,化学反应生成4-苯基丁酰氯
参考文献:Kipping; Hill,Journal Of The Chemical Society,1899,Vol. 75,P. 151
标题:Kipping; Hill,Journal Of The Chemical Society,1899,Vol. 75,P. 151

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专利信息


专利号:US-4873342-A
优先权日:1985-04-16
标题:Dipeptide derivative and synthesis and use thereof
发明人：TANAKA TAKAHARU; SAITOH MASAYUKI; HIGUCHI NAOKI; HASHIMOTO MASAKI
权利人:SUNTORY LTD
摘要:A novel depeptide derivative which exhibits inhibitory activity against prolyl endopeptidase and is effective for preventing and curing amnesia is disclosed. A process for chemical synthesis of such a derivative, as well as its use, is also disclosed.

专利号:US-4757083-A
优先权日:1985-11-29
标题 :Novel pyrrolidinylamide ester derivatives having anti-prolyl endopeptidase activity and synthesis and use thereof
发明人：HIGUCHI NAOKI; SAITOH MASAYUKI; HASHIMOTO MASAKI; FUKAMI HARUKAZU; TANAKA TAKAHARU
权利人:SUNTORY LTD
摘要:A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula: ##STR1## wherein n is 0 or an integer of 1 to 7 and R is hydrogen atom or a straight or branched alkyl having 1 to 8 carbon atoms.

专利号:CN-101633611-A
优先权日:2009-08-20
标 题 :A kind of method of gas-solid phase reaction synthesis α-tetralone

专利号:CN-112094182-A
优先权日:2020-09-22
标 题 :A kind of green synthesis method of pharmaceutical intermediate benzocyclohexanone compound

专利号:RU-2174511-C2
优先权日:1996-07-23
标 题 :Amides of alpha-amino acids, their synthesis and therapeutic use

专利号:CN-112094182-B
优先权日:2020-09-22
标题:Green synthesis method of medical intermediate benzocyclohexanone compound

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合成参考文献


摘要:Guerrero, C. A., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2, 213.
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