CAS: 160514-13-6; (2'-(2H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methanol

上下游产品

5-(2-bromophenyl)-1H-tetrazole p-hydroxymethylphenylboronic acid 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile 2-(tetrahydro-pyran-2-yl)-5-[4'-(tetrahydro-pyran-2-yloxymethyl)-biphenyl-2-yl]-2H-tetrazole 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde 4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl -4-methanol2'-2-(triphenylmethyl)-1H-tetrazol-5-yl1,1'-biphenyl-4-methanol

4-(2-氰基苯基)苄醇置于sodium Azide,Zinc(II) Chloride体系中,用 正丁醇 用作溶剂,化学反应 20.0H,以88.7%的收率获得2'-(2H-四唑-5-基)-[1,1'-联苯]-4-甲醇
参考文献:一种制备5-(4'-溴代甲基-2-联苯基)-1-三苯 甲基四氮唑的方法
标题:一种制备5-(4'-溴代甲基-2-联苯基)-1-三苯 甲基四氮唑的方法
摘要:本发明公开了一种制备5-(4'-溴代甲基-2-联苯基)-1-三苯甲基四氮唑的方法,以2-氰基联苯代替传统工艺中的2-氰基-4'-甲基联苯为起始原料,依次通过羟甲基化,环合,保护,取代反应得到目标产物5-(4'-溴代甲基-2-联苯基)-1-三苯甲基四氮唑.该方法具有原料成本低,溶剂回收方便,综合污染少等优点,适合于工业化生产.

专利信息

专利号:US-7728024-B2
优先权日:2005-07-11
标 题:Metal salts of 2′-(1H-Tetrazol-5yl)-1.1′-biphenyl-4-carboxaldehyde
发明人：SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE
权利人:NOVARTIS AG
摘要:The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA, n nor a tautomer thereof, wherein [kat] n+ is a cation and n is 1, 2, 3, 4, 5 or 6.

专利号:RU-2426728-C2
优先权日:2004-02-02
标 题 :Coupling reactions possibly used in synthesis of (1h-tetrazol-5-yl)biphenyl derivatives