CAS: 1603-03-8; 15-Methylpalmitic Acid

该化合物是一种分链式脂肪酸衍生物,其特点是以六十二硝酸主干体第15碳的甲基组替代,这种结构改变具有不同的物理化学特性,包括与线性对口相比,熔化行为和溶性特征的变化.该化合物对脂质研究,特殊化学合成和工业应用感兴趣,需要根据需要进行疏通的疏漏水性互动.其分支结构可以增强与某些聚合物或表面活性剂的兼容性,从而有可能成为需要修改粘度或相稳定性的配方的候选物.该化合物的纯性和一致性对于实验或生产环境中的可复制性至关重要.

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2724-58-5 4669-02-7 5963-14-4

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5-ethoxy-5-oxopentanoic acid isomyristic acid (+/-)-16-methyl-heptadecane-1,2,16-triol

合成工艺路线路线简述

    📜15-Methylhexadecan-1,15-Diol置于三乙基硅烷,Potassium Permanganate,三氟化硼乙醚,四丁基溴化铵,溶剂黄146体系中,用 二氯甲烷,水 用作溶剂,化学反应 24.75H,反应生成15-甲基十六烷酸
    参考文献:长链异脂肪酸 (Iso-C12-C19) 和相关天然产物的实用合成.
    标题:长链异脂肪酸 (Iso-C12-C19) 和相关天然产物的实用合成.
    摘要:从十一碳烯酸甲酯(十一碳烯酸甲酯)(对于异 C12-C14)或 C15 和 C16 内酯十五烷内酯开始,开发了末端支化异脂肪酸(iso-C12-C19)的克级合成(异-C15-C17)和十六烷内酯(异-C18-C19).概述的方法的核心是通过将甲基溴化镁添加到酯/内酯和选择性还原所得叔醇来两步构建末端异丙基.因此,C12,C17 和 C18 异脂肪酸是从市售原料中分三步获得的,其余的 C13-C16 和 C19 异脂肪酸通过这些脂肪酸的同系或递归脱同系或通过拦截来制备合适的中间体.
    Doi:10.3762/bjoc.9.210

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-2017246690-A1
    优先权日:2014-06-20
    标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom
    发明人:MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND
    权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA
    摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.

    专利号:US-6214875-B1
    优先权日:1998-04-14
    标题:Anticancer effects of specific branched-chain fatty acids and related production process
    发明人:YANG ZHENHUA
    摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

    专利号:CN-106852132-A
    优先权日:2014-06-20
    标题:Stabilizer-free synthesis of metal nanoparticles and use of metal nanoparticles synthesized therefrom

    专利号:MX-2007005591-A
    优先权日:2004-11-08
    标 题:SYNTHESIS OF CARDIOLIPINE ANALOGS AND USES OF THE SAME.

    专利号:CN-1714095-A
    优先权日:2002-10-16
    标题:Cardiolipin molecules and method of synthesis

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: A A Aliero, Et Al. Volatile Components From The Roots Of Solanum Pseudocapsicum. J Med Food. 2007 Sep;10(3):557-8.
    [参考文献]: Kyleann K Brooks, Et Al. The Influence Of Bacterial Diet On Fat Storage In C. Elegans. Plos One. 2009 Oct 21;4(10):E7545.
    [参考文献]: Myung Soo Park, Et Al. Chryseobacterium Soldanellicola Sp. Nov. And Chryseobacterium Taeanense Sp. Nov., Isolated From Roots Of Sand-Dune Plants. Int J Syst Evol Microbiol. 2006 Feb;56(Pt 2):433-438.

    合成参考文献


    参考文献:10.1007/s11418-007-0187-y
    摘要:Takeda Y, Tomonari M, Arimoto S, Masuda T, Otsuka H, Matsunami K, Honda G, Ito M, Takaishi Y, Kiuchi F, Khodzhimatov OK, Ashurmetov OA. A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum. Journal of Natural Medicines. 2007 Aug 10;62(1):71–4. doi: 10.1007/s11418-007-0187-y.
    参考文献:10.1007/bf02532714
    摘要:Norén B, Odham G. Antagonistic effects of Myxococcus xanthus on fungi. II. Isolation and characterization of inhibitory lipid factors. Lipids. 1973 Oct;8(10):573–83. doi: 10.1007/bf02532714.
    参考文献:10.1007/bf02532504
    摘要:Conner RL, Koo KE, Landrey JR. Isovaleric acid as a precursor of odd numbered iso fatty acids in Tetrahymena. Lipids. 1974 Aug;9(8):554–9. doi: 10.1007/bf02532504.
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