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1,3-二氟苯置于三氟甲磺酸,三氯异氰尿酸体系中,化学反应 14.0H,以90%的收率获得2,4-二氟氯苯
参考文献:具有吸电子取代基的芳烃催化亲电卤化
标题:具有吸电子取代基的芳烃催化亲电卤化
摘要:芳烃的亲电卤化可能是制备芳基卤化物的最简单方法,芳基卤化物是农用化学品,材料和药物中的重要结构基序.然而,芳烃的亲核性被吸电子取代基削弱,其亲电子卤化反应通常需要苛刻的条件,导致底物范围和应用受到限制.因此,在温和条件下卤化含有吸电子基团(ewgs)和复杂生物活性化合物的芳烃一直是一个长期的挑战.在此,我们描述了在温和条件下具有吸电子取代基的芳烃的 Brønsted 酸催化卤化,为芳基卤化物提供了一种有效的方案.布朗斯台德酸与质子溶剂 1,1,1,3,3 的氢键,
Doi:10.1021/jacs.2C06440

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:US-7393980-B2
优先权日:2001-05-17
标题:Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
发明人：GARAYT MAXIME; LE BOULAIRE VIRGINIE; GREE DANIELLE; GREE RENE; SCHANEN VINCENT; SPINDLER JEAN-FRANCIS
权利人:RHODIA CHIMIE SA
摘要:The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:KR-20230134489-A
优先权日:2021-01-20
标题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:CN-116724021-A
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides