CAS: 14287-21-9; Ac-Phe-Lys-Oh

上下游产品

L-lysine (S)-2-acetylamino-3-phenylpropanoic acid L-Lysine hydr°Chloride

📜Methyl 4-[[(E)-3-[4-(3-Aminophenyl)Sulfanyl-2,3-Bis(Trifluoromethyl)Phenyl]Prop-2-Enoyl]Amino]Bicyclo[2.2.2]octane-1-Carboxylate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 0.03H,反应生成乙酰基-苯甲氨酰-赖氨酸
参考文献:Photogenerated Reagents
标题:Photogenerated Reagents
摘要:这项发明描述了试剂前体和化学以及生物化学反应的方法.这些试剂前体可以在溶液中被激发后激活,产生后续化学反应所需的试剂.具体来说,光生试剂(pgr)对于控制并行组合合成和各种化学以及生物化学反应非常有用.

专利信息

专利号:US-2023248849-A1
优先权日:2020-07-27
标 题:Contrast agents for detection of enzyme activities based on melanin synthesis
发明人：PAGEL MARK D
权利人:UNIV TEXAS
摘要:We disclose a composition, comprising a compound, comprising a melanin precursor that spontaneously synthesizes a melanin when in free form in vivo, and a peptide directly covalently bonded to or indirectly linked to the melanin precursor, wherein the direct covalent bond or indirect link of the peptide to the melanin precursor blocks spontaneous synthesis of the melanin in vivo in the absence of protease activity. We also disclose methods of tumor imaging, tumor detection, diagnosis, and treatment, including methods comprising administering, to a patient suffering from a tumor, the composition; and either surgically resecting the tumor or thermally ablating the tumor, wherein the surgical resection is guided at least in part by contrast imparted by, or the thermally ablating targets cells containing, the melanin, wherein the melanin is spontaneously synthesized in the tumor after administering the composition.