CAS: 1416134-47-8; (2S,5R)-Ethyl 5-((Benzyloxy)Amino)Piperidine-2-Carboxylate
该化合物是复杂的有机化合物,其特征是管状内基结构,包括一个碳箱酯功能组和一个苯基氧氨基替代体.该化合物在特定位置具有立体化学特征,以(2s,5r)配置为特征,表明一种明确的三维安排能够影响其生物活动和相互作用. 氧酸盐形式的存在表明它有可能在极溶剂中更容易溶解,从而增强其在制药配方中的潜在应用. 苯氧基化合物的脂性可能影响到其渗透性和生物系统吸收.
- 英文名称(2S,5R)-Ethyl 5-((Benzyloxy)Amino)Piperidine-2-Carboxylate
- 中文名称阿维巴坦中间体
- IUPAC名称ethyl (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate
- 其它别名(2S,5R)-Ethyl 5-(Benzyloxyamino)Piperidine-2-Carboxylate; (2S,5R)-Ethyl 5-((Benzyloxy)Amino)Piperidine-2-Carboxylate Oxalate; 2-Piperidinecarboxylic Acid, 5-[(Phenylmethoxy)Amino]-, Ethyl Ester, (2S,5R)-; Ethyl (2S,5R)-5-[(Phenylmethoxy)Amino]-2-Piperidinecarboxylate
- CAS编号1416134-47-8
- MFCD编号:MFCD30533001
- FDA UNII编号:MUS88Q3BPH
- 分子式:C15H22N2O3分子量:278.35
- 产品CID: 635444
MSDS等安全信息
上下游产品
6-sulfanylidene)-5-oxohexanoateethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate (S)-ethyl N-tert-butoxycarbonylpyroglutamate (S)-ethyl 2-(((tert-butoxy)carbonyl)amino)-6-diazo-5-oxohexanoate O-benzylhydoxylamine hydr°Chloride(2R,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]°Ctane-2-carboxylic acid合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:WO-2025027521-A1
优先权日:2023-08-01
标题 :An improved process for the preparation of avibactam and intermediate thereof
发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.
