CAS: 128917-74-8; Fmoc-12-Ado-Oh

相似化合物

18934-81-1 693-57-2 126631-93-4

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号693-57-2 12-氨基十二酸

📜9-芴甲基-N-琥珀酰亚胺基碳酸酯,12-氨基十二酸置于碳酸氢钠体系中,用 水,丙酮 用作溶剂,化学反应 20.0H,以43%的收率获得fmoc-12-氨基十二烷酸
参考文献:通过固相合成制备酶活化毒胡萝卜素前药.
标题:通过固相合成制备酶活化毒胡萝卜素前药.
摘要:由于实体瘤中的细胞分裂速度不如骨髓中的细胞或免疫系统细胞,因此有丝分裂抑制剂在用于治疗前列腺癌和乳腺癌等疾病时通常会引起严重的副作用.克服这个问题的一种方法是尝试开发基于一般细胞毒素的药物,如加利车霉素和毒胡萝卜素,它们在细胞周期的所有阶段杀死细胞.然而,只有在可能有效靶向恶性组织时才能使用此类毒素.在毒胡萝卜素的情况下,通过将药物与仅在肿瘤附近裂解的肽结合以释放细胞毒性药物或具有保留活性的类似物来实现对肿瘤相关细胞的选择性.
Doi:10.3390/molecules23061463

专利信息

专利号:US-7799524-B2
优先权日:2002-10-03
标 题:Substrates for O6-alkylguanina-DNA alkyltransferase
发明人：KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH
权利人:ECOLE POLYTECHNIQUE FERDEALE D
摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.