CAS: 1173-26-8; 2-((8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-10,13-Dimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-2-Oxoethyl Acetate
该化合物是肾上腺皮质激素产生的类固醇类激素的合成衍生物,被归类为胆固醇类,主要用于研究和治疗用途,因为其抗炎和免疫抑制特性,该物质是白色的,可溶于白晶状粉,在乙醇和乙醇等有机溶剂中溶解,但水溶性有限.其分子结构包括一种含有乙酸盐的类固醇脊椎,可增加其脂性和生物利用率.在与应激反应,代谢和内分泌功能有关的研究中,常使用丙醇酮乙酸盐.在实验室环境中,该物质可被动物模型管理,以调查其生理影响或发展对诸如自动免疫性疾病和过敏性等条件的治疗.与其他甘醇类动物一样,对于其使用应谨慎谨慎,因为它可能导致副作用,如荷尔蒙失衡和不端使用甲酸性.
- 英文名称2-((8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-10,13-Dimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-2-Oxoethyl Acetate
- 中文名称2-((8S,9S,10R,11S,13S,14S,17S)-11-羟基-10,13-二甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-四氢-1h-环戊二烯-17-基)-2-氧代乙酸乙酯
- IUPAC名称[2-[(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- 其它别名21-乙酸肾上腺酮; Corticosterone Acetate
- CAS编号1173-26-8
- MFCD编号:MFCD00010482
- EINECS号:214-635-8
- FDA UNII编号:KN17U0V6BL
- 分子式:C23H32O5分子量:388.5
- 产品CID: 221486
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
50-03-3 1625-11-2 81968-66-3物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号50-22-6 肾上腺酮 | CAS号108-24-7 乙酸酐 | CAS号50-23-7 氢化可的松 | CAS号565-92-4 5β-pregnan-3α,1... | CAS号48200-75-5 (3β,5β,11β)-3,1... | CAS号57717-92-7 3β.11β-dihydrox... | CAS号463-51-4 乙烯酮 | CAS号7726-95-6 溴素 | CAS号64-19-7 冰醋酸 | CAS号50-22-6 肾上腺酮 | CAS号298-25-9 5-Alpha-二氢皮质酮合成工艺路线路线简述
- 合成目标产物 Corticosterone 21-Acetate 主要起始原料 Corticosterone And Acetic Anhydride
- (文献来源)合成步骤主要原料 Corticosterone 和 Acetic Anhydride
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-3631031-A
优先权日:1965-06-11
标题:Intermediate useful in the synthesis of aldosterone
专利号:US-3709789-A
优先权日:1965-06-11
标题:Biochemical aldosterone synthesis
发明人：KONDO E; MITSUGI T; TORI K
权利人:SHIONOGI & CO
摘要:CORTICOSTERONE OR ESTERS THEREOF IS TREATED WITH THE ENZYMES OF CORYNESPORA FUNGUS TO OBTAIN NOVEL 18-HYDROXYCORTISOSTERONE INTER- AND/OR INTRA-MOLECULAR ACETALS AND/OR ACYLATES THEREOF ACCOMPANIED WITH SEVERAL MONOHYDROXYCORTICOSTERONES, THEN THE PRODUCT IS TREATED WITH ACID OR MIXTURE OF ACID AND ACYLATING AGENT TO FORM ETHER BRIDGE BETWEEN POSITIONS 11 AND 18, FINALLY THE 18-DEOXYALDOSERONE DERIVATIVES OBTAINED ARE TREATED AGAIN WITH THE ENZYMES OF CORYNESOPRA FUNGUS TO PREPARE ALDOSTERONE, 18-DEHYDROALDOSTERONE, 9A-HYDROXY-11B,18-EPOXY-4-ANDROSTENE-3,17-DIONE.
专利号:US-3780026-A
优先权日:1969-01-13
标 题 :Biochemical aldosterone synthesis
发明人：KONDO E; MITSUGI T; TORI K
权利人:SHIONOGI & CO
摘要:CORTICOSTERONE OR ESTERS THEREOF IS TREATED WITH THE ENZYMES OF CORYNESPORA FUNGUS TO OBTAIN NOVEL 18-HYDROXYCORTICOSTERONE INTER- AND/OR INTRA-MOLECULAR ACETALS AND/OR ACYLATES THEREOF ACCOMPANIED WITH SEVERAL MONOHYDROXYCORTICOSTERONES, THEN THE PRODUCT IS TREATED WITH ACID OR MIXTURE OF ACID AND ACYLATING AGENT TO FORM ETHER BRIDGE BETWEEN POSITIONS 11 AND 18, FINALLY THE 18-DEOXYALDOSTERONE DERIVATIVES OBTAINED ARE TREATED AGAIN WITH THE ENZYMES OF DORYNESPORA FUNGUS TO PREPARE ALDOSTERONE, 18-DEHYDROALDOSTERONE, 9A-HYDROXY-11B,18-EPOXY-4ANDROSTENE-3,17-DIONE.
专利号:US-3000882-A
优先权日:1954-07-30
标 题 :Process for the synthesis of 18-homoandrostane-compounds
发明人：ALBERT WETTSTEIN; GEORG ANNER; KARL HEUSLER; HELLMUT UEBERWASSER; PETER WIELAND; JULIUS SCHMIDLIN; JEAN-RENE BILLETER
权利人:CIBA PHARM PROD INC
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: B L Tepperman, Et Al. Ontogeny Of Gastric Mucosal Permeability Responses To Luminal H+ And Bile Salt In The Rat. Am J Physiol. 1986 May;250(5 Pt 1):G617-24.[参考文献]: B R Sankar, Et Al. Chronic Administration Of Corticosterone Impairs Lh Signal Transduction And Steroidogenesis In Rat Leydig Cells. J Steroid Biochem Mol Biol. 2000 Mar;72(3-4):155-62.
[参考文献]: G Barseghian, Et Al. Effect Of Corticosterone On Carbamylcholine-, Leucine-, Or Calcium-Induced Insulin Secretion By The Isolated Perfused Rat Pancreas. Endocrinology. 1984 Apr;114(4):1086-9.
[参考文献]: G Valli, Et Al. Influence Of Corticosterone Acetate On The Spleen In Intact And Ovariectomized Rats. Endocrinol Jpn. 1992 Dec;39(6):549-54.
[参考文献]: H Okahata, Et Al. Development Of Gastric Somatostatin-Like Immunoreactivity In Response To Corticosterone Acetate And Dietary Changes In Young Rats. Acta Endocrinol (Copenh). 1986 Jul;112(3):383-7.
合成参考文献
摘要:Treacy, S. M.; Zhang, X.; Rovis, T., Science of Synthesis, (2021) , 627.
参考文献:10.14670/hh-19.693
摘要:Franchini A, Marchesini E, Ottaviani E. Corticosterone 21-acetate in vivo induces acute stress in chicken thymus: cell proliferation, apoptosis and cytokine responses. Histol Histopathol. 2004 Jul;19(3):693–9. doi: 10.14670/hh-19.693.
参考文献:10.1007/bf03033156
摘要:Barros VG, Boado LA, Adamo AM, Caviedes R, Caviedes P, Antonelli MC. Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line. Neurotox Res. 2003;5(5):369–73. doi: 10.1007/bf03033156.
📝 需求与反馈
尽可能描述清楚需求与问题信息
