CAS: 110882-60-5; 3-Fluoro-5-Nitrobenzonitrile

相似化合物

210992-28-2 108159-96-2 14027-75-9

上下游产品

CAS号3819-88-3 1-氟-3-碘-5-硝基苯 | CAS号557-21-1 氰化锌 | CAS号619-24-9 间硝基苯腈 | CAS号4110-35-4 3,5-二硝基苯甲腈 | CAS号544-92-3 氰化亚铜 | CAS号7087-65-2 3-溴-5-氟苯胺 | CAS号364-78-3 4-氟-2-硝基苯胺 | CAS号10472-88-5 2-溴-4-氟-6-硝基苯胺 | CAS号210992-28-2 5-氨基-3-氟苯腈 | CAS号108159-96-2 3-氟-5-硝基苯甲醛 | CAS号14027-75-9 3-氟-5-硝基苯甲酸 | CAS号883987-74-4 3-氟-5-硝基苯甲醇

4-氟-2-硝基苯胺置于copper(I) Oxide,硫酸,溴,亚膦酸,Sodium Nitrite体系中,用 溶剂黄146,N,N-二甲基甲酰胺 用作溶剂,化学反应 9.42H,反应生成3-氟-5-硝基苯腈
参考文献:Directed Biosynthesis Of 5''-Fluoropactamycin In Streptomyces Pactum.
标题:Directed Biosynthesis Of 5''-Fluoropactamycin In Streptomyces Pactum.
摘要:一种新的孔雀霉素类似物5"-氟孔雀霉素通过定向生物合成法制备而成.通过在孔雀霉素链霉菌(streptomyces Pactum)发酵培养基中添加3-氨基-5-氟苯甲酸(3-Amino-5-Fluorobenzoic Acid),这种化合物是3-氨基苯甲酸的类似物,而3-氨基苯甲酸是孔雀霉素生物合成中的一种高级前体,从而导致了孔雀霉素和新的孔雀霉素类似物的共同生产.与3-氨基-5-甲基苯甲酸的类似喂养实验未能产生相应的甲基化孔雀霉素类似物,仅导致了孔雀霉素生产的抑制.对孔雀霉素和5"-氟孔雀霉素的抗菌和细胞毒活性比较显示没有显著差异.
Doi:10.7164/antibiotics.47.1456

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.