CAS: 104324-16-5; (S)-4-Benzyl-3-(2-Chloroacetyl)Oxazolidin-2-One

该化合物是作为非对称合成中辅助试剂广泛使用的一种手性氧化氮丁酮衍生物,其主要优点包括:在授糖,相互交融和阿道反应中具有高对等选择性,在复杂的有机变异中能够进行精确的立体化学控制;叶酸基会增强反应性,促进在温和条件下高效衍生;苯基组提供静态和电子稳定,提高产量和选择性;该化合物在制药和精细化学合成中特别有用,在这种合成中,阳性纯度至关重要;其在不同反应条件下的强性表现使合成化学家在寻求可靠的对应选择性方法时成为首选.

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101711-78-8 131685-53-5 129952-14-3

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号90719-32-7 |S|-4-苄基-2-恶唑烷酮 | CAS号79-04-9 氯乙酰氯 | CAS号63-91-2 L-苯丙氨酸 | CAS号3182-95-4 L-苯丙氨醇

合成工艺路线路线简述

    📜L-苯丙氨醇置于正丁基锂,Potassium Carbonate体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 2.5H,反应生成N-氯乙酰基-(4S)-苄基-2-恶唑烷酮
    参考文献:不对称甘氨酸烯醇醛醇反应:环孢菌素不寻常氨基酸 Mebmt 的合成
    标题:不对称甘氨酸烯醇醛醇反应:环孢菌素不寻常氨基酸 Mebmt 的合成
    摘要:合成 De L'Acide (Hydroxy-3Methyl-4Methylamino-2) octene-6Oique Apr Aldolisation Entre L'Enolate De La (Benzyl-4 Isothiocyanatoacetyl-3) Oxazolidone-2 Et Des Alcenals
    Doi:10.1021/ja00281A049

    专利信息


    专利号:US-5012000-A
    优先权日:1989-10-30
    标 题 :Total synthesis of chiral 2-amino-1,3-diols
    发明人：ILLIG CARL R; WEIS ALEXANDER L
    权利人:EASTMAN KODAK CO
    摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.

    专利号:EP-1243591-A2
    优先权日:2001-03-19
    标题 :Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

    专利号:US-2004138487-A1
    优先权日:2001-03-19
    标 题 :Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

    专利号:US-6689915-B2
    优先权日:2001-03-19
    标 题:Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

    专利号:US-2002143214-A1
    优先权日:2001-03-19
    标 题:Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

    专利号:JP-2002338586-A
    优先权日:2001-03-19
    标题:Synthesis of non-C2 symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

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    主要参考文献

    参考标题:Synthesis Of Iso-Epoxy-Amphidinolide N And Des-Epoxy-Caribenolide I Structures. Initial Forays
    作者:K. C. Nicolaou,William E. Brenzovich,Paul G. Bulger,Tasha M. Francis
    摘要:Two Strategies For The Projected Total Synthesis Of The Phenomenally Potent Antitumour Macrolides Amphidinolide N (1) And Caribenolide I (2) Are Described. The Title Compounds Are Introduced As Challenging And Unique Targets For Chemical Synthesis, And Their Retrosynthetic Analysis Is Presented. The Synthesis Of The Four Defined Key Building Blocks (10, 39, 67 And 72), Required For The Construction

    合成参考文献

    参考DOI号:10.5012/bkcs.2010.31.03.653
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