CAS: 10109-05-4; β-(1,2,4-Triazol-3-yl)-Dl-Alanine

相似化合物

844439-07-2 1495042-48-2 1690018-03-1

上下游产品

diethyl 2-formylaminomalonate

📜在 盐酸体系中,化学反应 12.0H,反应生成1,2,4-噻唑-3-丙氨酸
参考文献:Ogrel',An. A.; Zvonkova,E. N.; Gafurov,R. G.,Russian Journal Of Bioorganic Chemistry,1993,Vol. 19,# 9,P. 527-533
标题:Ogrel',An. A.; Zvonkova,E. N.; Gafurov,R. G.,Russian Journal Of Bioorganic Chemistry,1993,Vol. 19,# 9,P. 527-533

专利信息

专利号:WO-2020237701-A1
优先权日:2019-05-30
标题:High-yield l-histidine genetically engineered bacterium strain, and construction method therefor and application thereof
发明人：XIE XIXIAN; ZHANG YUE; FAN WEIMING; JIANG WEI; WU HEYUN; CHEN YANNA; TIAN DAOGUANG; TU JIANQING
权利人:TIANJIN UNIV OF SCIENCE&TECHNOLOGY; ZHEJIANG ZHENYUAN PHARMACEUTICAL CO LTD
摘要:Provided are a high-yield L-histidine genetically engineered bacterium strain, and a construction method therefor and an application thereof, integrating a corynebacterium glutamicum ATP phosphoribosyl transferase HisG mutant encoding gene into a genome of escherichia coli to enhance the activity of HisG, also increasing the number of copies of histidine operon genes in the genome to enhance synthesis of histidine, and integrating an encoding gene lysE of arginine/lysine transport protein derived from the corynebacterium glutamicum into the genome to promote extracellular secretion of intracellular histidine. The genetically engineered bacterium is used for producing the L-histidine by a fermentation method, can stably produce 40-55 g/L of the histidine by fermentation in a 5 L fermentation tank for 40-50 h, has a production intensity reaching 1.0-1.5 g/(Lxh), and has a conversion rate of 0.18-0.22 g histidine/g glucose.

专利号:US-5236831-A
优先权日:1981-12-29
标 题:Amino acid synthesis in corynebacteria using E. coli genes
发明人：KATSUMATA RYOICHI; OZAKI AKIO; MIZUKAMI TORU; KAGEYAMA MOTOKO; YAGISAWA MORIMASA; MIZUKAMI TAMIO; ITOH SEIGA; OKA TETSUO; FURUYA AKIRA
权利人:KYOWA HAKKO KOGYO KK
摘要:Disclosed is a process for expressing a gene and producing a metabolic product formed by the gene by culturing a transformant microorganism carrying a recombinant DNA constructed of a DNA fragment having at least one gene to be expressed and a vector DNA, at least one of which is foreign to the host microorganism.