128-37-0 = 88-26-6 反应条件:1.1 Reagents: Benzenemethanaminium,N,N,N-Trimethyl-,Dichlorobromate(1-) (1:1) Solvents: Dichloromethane,Water; Rt; 3 H,Rt 标题:Oxidation Of 2,6-Di-T-Butyl-4-Methylphenol And Its Derivatives With Tetraalkylammonium Dichlorobromate(1-) 作者:Kimura,Noriyosi; Et Al 参考文献:Wakayama Daigaku Kyoikugakubu Kiyo 日期:2009 卷标:59 页码:33-38]
1620-98-0 = 88-26-6 反应条件:1.1 Reagents: (T-4)-Trihydro(Methanamine)Boron Solvents: Water; 30 Min,Rt 标题:Hydrogenation Of Aldehydes And Ketones To Corresponding Alcohols With Methylamine Borane In Neat Water 作者:Duan,Yifan; Et Al 参考文献:Synthetic Communications 日期:2014 卷标:44(17) 页码:2555-2564]
10396-80-2 = 88-26-6 [标题:Reaction Conditions 标题:Reactions Of 4-Hydroxycyclohexa-2,5-Dienones Under Acidic Conditions 作者:Davis,Brian R.; Et Al 参考文献:Journal Of The Chemical Society 日期:1982 卷标:(7) 页码:1499-507]
83638-63-5 = 88-26-6 反应条件:1.1 Reagents: Perchloric Acid 标题:Reactions Of 4-Hydroxycyclohexa-2,5-Dienones Under Acidic Conditions 作者:Davis,Brian R.; Et Al 参考文献:Journal Of The Chemical Society 日期:1982 卷标:(7) 页码:1499-507]
1074-82-4 + 14387-17-8 = 88-26-6 反应条件:1.1 Solvents: Dimethyl Sulfoxide; 1 H,70 °C2.1 Reagents: Water 标题:Synthesis Of 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Amine From 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Acetate 作者:Bukharov,S. V.; Et Al 参考文献:Vestnik Kazanskogo Tekhnologicheskogo Universiteta 日期:2013 卷标:16(6) 页码:30-32]
501-65-5 + 37181-39-8 = 88-26-6 反应条件:1.1 Solvents: Dichloromethane-D2,Water; 5 Min,Rt; Rt 标题:Synthesis And Reactivity Of The Methylene Arenium Form Of A Benzyl Cation,Stabilized By Complexation 作者:Poverenov,Elena; Et Al 参考文献:Journal Of The American Chemical Society 日期:2006 卷标:128(51) 页码:16450-16451]
121115-33-1 = 88-26-6 反应条件:1.1 Solvents: Tetrahydrofuran; -30 °C; 30 Min,-30 °C2.1 Solvents: Dichloromethane-D2; -30 °C; 10 Min,-30 °C; 1 H,-30 °C -> Rt3.1 Solvents: Dichloromethane-D2,Water; 5 Min,Rt; Rt 标题:Synthesis And Reactivity Of The Methylene Arenium Form Of A Benzyl Cation,Stabilized By Complexation 作者:Poverenov,Elena; Et Al 参考文献:Journal Of The American Chemical Society 日期:2006 卷标:128(51) 页码:16450-16451]
128-37-0 = 88-26-6 反应条件:1.1 Reagents: Benzyltrimethylammonium Tribromide Solvents: Dichloromethane,Water 标题:Oxidation Using Quaternary Ammonium Polyhalides. Ix. Oxidation Of Hindered Phenols With Benzyltrimethylammonium Tribromide 作者:Kajigaeshi,Shoji; Et Al 参考文献:Bulletin Of The Chemical Society Of Japan 日期:1991 卷标:64(3) 页码:1060-2]
128-37-0 = 88-26-6 反应条件:1.1 Reagents: Bromine Solvents: Tert-Butanol; 1 H,40 °C; 0.5 H,40 °C 标题:An Improved Preparation Of 2,6-Di-(T-Butyl)-4-Methylphenol 作者:Xie,J. Y.; Et Al 参考文献:Organic Preparations And Procedures International 日期:2015 卷标:47(3) 页码:236-241]
1620-98-0 = 88-26-6 反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; Rt 标题:Unusual Transformation Of 4-Hydroxy/methoxybenzylic Alcohols Via C-C Ipso-Substitution Reaction Using Proton-Exchanged Montmorillonite As Media 作者:Chen,Xuan; Et Al 参考文献:Tetrahedron Letters 日期:2020 卷标:61(48)]
2607-52-5 = 88-26-6 反应条件:1.1 Reagents: Water 标题:Synthesis Of 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Amine From 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Acetate 作者:Bukharov,S. V.; Et Al 参考文献:Vestnik Kazanskogo Tekhnologicheskogo Universiteta 日期:2013 卷标:16(6) 页码:30-32]
2607-52-5 = 88-26-6 反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetonitrile,Water; Rt 标题:Hydrolysis Of The Quinone Methide Of Butylated Hydroxytoluene In Aqueous Solutions 作者:Willcockson,Maren Gulsrud; Et Al 参考文献:Journal Of Pharmaceutical Sciences 日期:2013 卷标:102(10) 页码:3579-3585]
128-39-2 = 88-26-6 反应条件:1.1 Catalysts: Boric Acid (H3Bo3)2.1 Reagents: Sodium Borohydride Solvents: Acetonitrile 标题:Oxidation Of 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Alcohol And 3,5-Di-Tert-Butyl-4-Hydroxybenzaldehyde With Oxygen In Aqueous Ammonia Solutions 作者:Fedulina,T. G.; Et Al 参考文献:Zhurnal Organicheskoi Khimii 日期:1989 卷标:25(8) 页码:1706-15]
= 88-26-6 反应条件:1.1 Catalysts: P-Toluenesulfonic Acid; Heated; 9 H,56 °C1.2 Catalysts: Thiourea Solvents: Water; Cooled; 80 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 7.5,80 °C2.1 Reagents: Bromine Solvents: Tert-Butanol; 1 H,40 °C; 0.5 H,40 °C 标题:An Improved Preparation Of 2,6-Di-(T-Butyl)-4-Methylphenol 作者:Xie,J. Y.; Et Al 参考文献:Organic Preparations And Procedures International 日期:2015 卷标:47(3) 页码:236-241]
333-27-7 = 88-26-6 反应条件:1.1 Solvents: Dichloromethane-D2; -30 °C; 10 Min,-30 °C; 1 H,-30 °C -> Rt2.1 Solvents: Dichloromethane-D2,Water; 5 Min,Rt; Rt 标题:Synthesis And Reactivity Of The Methylene Arenium Form Of A Benzyl Cation,Stabilized By Complexation 作者:Poverenov,Elena; Et Al 参考文献:Journal Of The American Chemical Society 日期:2006 卷标:128(51) 页码:16450-16451
专利号:US-7825257-B1 优先权日:2007-10-23 标题 :Synthesis of benzotriazole monomer 发明人:DEO KESHAV; SHAH CHANDRAKANT CHUNILAL; PATEL KALPESH; PATEL NILPESH; PAREKH VIRAL; PATEL RONAK; SONI JIGNESH; SHAH HIRAL; SEELYE DAVID E; NANDU MAHENDRA P 权利人:BAUSCH & LOMB 摘要:The synthesis of benzotriazole monomers and the use of the benzotriazole monomers and one or more other monomers to prepare ultraviolet (UV) light absorbing polymer compositions. The synthetic methods described in this application provide a significant improvement over the previous methods used to prepare benzotriazole monomers.
专利号:US-8106031-B2 优先权日:2006-05-02 标题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:US-7056348-B2 优先权日:2001-04-19 标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers 发明人:SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA 权利人:WELLA AG 摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.
专利号:US-5364974-A 优先权日:1993-12-21 标 题 :Process for the preparation of 3,5-di-tert-butyl-4-hydroxy methoxybenzyl alcohol 发明人:PANTUKH BORIS I; LOGUTOV IGOR J; LJUBIMOV NIKOLAI V; RUTMAN GRIGORY I 权利人:STERLITAMAXKY NEFTEKHIMICHESKY 摘要:Claimed is a process for the preparing 3,5-di-tert-butyl-4-hydroxy-methoxybenzyl alcohol which is an effective stabilizer of polymer materials and a starting compound in synthesis of high- effective polynuclear phenolic stabilizers. It is an object of this invention to provide a simplification of the process and improve a quality of the target product. This object is attained by using N,N,N',N'-tetra-methyl-methylene-bis-amine as a catalyst with the molar ratio of 2,6-DTBP to formaldehyde to methanol to bis-amine as of 1.0:1.0-1.5:10-15: 0.01-0.50 and conducting a process at 60 DEG -100 DEG C.
专利号:US-11273138-B2 优先权日:2017-11-02 标 题 :Use of amino acid supplementation for improved muscle protein synthesis 发明人:WOLFE ROBERT R; FERRANDO ARNY 权利人:BIOVENTURES LLC 摘要:The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.
专利号:US-4754077-A 优先权日:1982-12-16 标题:Antioxidant synthesis 发明人:MINA GEORGE L 权利人:ETHYL CORP 摘要:A process for making a 2,6-di-hydrocarbyl-4-alkoxyalkylphenol, e.g. 2,6-di-tert-butyl-4-methoxymethylphenol, by reacting a 2,6-dihydrocarbylphenol with formaldehyde in a stoichiometric excess of alcohol and in the presence of a Mannich base catalyst preferably formed in situ by adding a catalyst-forming amount of a secondary amine, e.g. dimethylamine, to the mixture of 2,6-di-hydrocarbylphenol, formaldehyde and alcohol. Unreacted alcohol and amine are distilled out and the 2,6-di-hydrocarbyl-4-alkoxyalkylphenol is reacted with a benzene-type compound, e.g. mesitylene, to make a hindered phenolic antioxidant, e.g. 1,3,5-trimethyl-2,4,6-tri-(3,5-di-tert-butyl-4-hydroxybenzyl)benzene.
[参考文献]: K D Munkres, Et Al. Ageing Of Neurospora Crassa. Iii. Induction Of Cellular Death And Clonal Senescence Of An Inositol-Less Mutant By Inositol Starvation And The Protective Effect Of Dietary Antioxidants. Mech Ageing Dev. 1976 May-Jun;5(3):163-9. [参考文献]: O L Brekke, Et Al. Butylated Hydroxyanisole Specifically Inhibits Tumor Necrosis Factor-Induced Cytotoxicity And Growth Enhancement. Cytokine. 1992 Jul;4(4):269-80. [参考文献]: X Guan, Et Al. Down-Regulation By Butylated Hydroxytoluene Of The Number And Function Of Gap Junctions In Epithelial Cell Lines Derived From Mouse Lung And Rat Liver. Carcinogenesis. 1995 Oct;16(10):2575-82. [参考文献]: Ying Shan Tan, Et Al. The Role Of Low Levels Of Water In The Electrochemical Oxidation Of α-Tocopherol (Vitamin E) And Other Phenols In Acetonitrile. Phys Chem Chem Phys. 2011 Jul 28;13(28):12745-54.
合成参考文献
摘要:Lumb, J.-P.; Esguerra, K. V. N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 610. 摘要:Toxicology and Applied Pharmacology., 17(669), 1970 [] 摘要:Guillet, E.; Malenfant, C.; Canesi, S., Science of Synthesis: Dearomatizations, (2026) . 参考文献:10.1016/j.envpol.2019.06.077 摘要:Liu R, Mabury SA. Unexpectedly high concentrations of 2,4-di-tert-butylphenol in human urine. Environ Pollut. 2019 Sep;252(Pt B):1423–8. doi: 10.1016/j.envpol.2019.06.077. 参考文献:10.1016/1043-4666(92)90067-2 摘要:Brekke OL, Shalaby MR, Sundan A, Espevik T, Bjerve KS. Butylated hydroxyanisole specifically inhibits tumor necrosis factor-induced cytotoxicity and growth enhancement. Cytokine. 1992 Jul;4(4):269–80. doi: 10.1016/1043-4666(92)90067-2.