CAS: 874638-80-9; ((2R,3R,4R)-3-(Benzoyloxy)-4-Fluoro-4-Methyl-5-Oxotetrahydrofuran-2-yl)Methyl Benzoate

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CAS号879551-04-9 核苷类中间体 | CAS号98-88-4 苯甲酰氯 | CAS号93635-76-8 2-C-甲基-4,5-O-(1... | CAS号1351925-17-1 (3R)-methyl 3-(... | CAS号1033394-83-0 ethyl (2R,3R)-3... | CAS号817204-32-3 (2'R)-N-苯甲酰基-2'...

(4S,5R)-5-((R)-2,2-二甲基-1,3-二氧戊环-4-基)-4-甲基-1,3置于盐酸,4-二甲氨基吡啶,Triethylamine Tris(Hydrogen Fluoride),三乙胺体系中,用 乙腈 作为反应溶剂,化学反应 8.5H,反应生成 ((2R,3R,4R)-3-(苯甲酰氧基)-4-氟-4-甲基-5-氧代四氢呋喃-2-基)苯甲酸甲酯
参考文献:一种索非布韦的中间体的制备方法
标题:一种索非布韦的中间体的制备方法
摘要:本发明的方法提供了一种d‑呋喃核糖内酯(结构式1)的3,5‑二‑o‑苯甲酰基‑2‑脱氧‑2‑氟代‑2‑c‑甲基‑d‑核糖‑γ‑内酯的制备方法,所述化合物是丙肝病毒(Hcv)Ns5B聚合酶抑制剂索非布韦的重要中间体.

专利信息

专利号:US-9845299-B2
优先权日:2013-01-14
标 题 :Process for the preparation of a fluorolacton derivative
发明人：CHEN RONGMIN; LI YUANQIANG; ZHAO JIANQIANG; ZHENG JIANBING; ZHU GUOLIANG
权利人:GILEAD PHARMASSET LLC
摘要:A novel process for the preparation of a fluorolactone derivative of the formula n n n n n n n n n n n n and of its acylated derivative of formula n n n n n n n n n n n n n n n n wherein R 1 stands for a hydroxy protecting group is described. n n n n n The acylated fluor lactones of formula V, particularly the benzoyl derivative with R 1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

专利号:US-9045520-B2
优先权日:2008-12-23
标题:Synthesis of purine nucleosides
发明人：CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN
权利人:CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN; GILEAD PHARMASSET LLC
摘要:A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

专利号:US-8669382-B2
优先权日:2010-06-03
标题 :Method for producing (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor
发明人：ISHII AKIHIRO; NAGURA HIROKATSU; TSURUTA HIDEYUKI
权利人:ISHII AKIHIRO; NAGURA HIROKATSU; TSURUTA HIDEYUKI; CENTRAL GLASS CO LTD
摘要:In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is useful as an important intermediate for the synthesis of 2′-deoxy-2′-fluoro-2′-C-methylcytidine with antivirus activity.

专利号:US-8716263-B2
优先权日:2008-12-23
标 题:Synthesis of purine nucleosides

专利号:US-2012316327-A1
优先权日:2008-12-23
标题 :Synthesis of purine nucleosides

专利号:US-2010279973-A1
优先权日:2008-12-23
标 题:Synthesis of purine nucleosides