CAS: 80047-24-1; 2-Methyl-6-Oxo-1,6-Dihydro-[3,4'-Bipyridine]-5-Carboxamide
该化合物是属于双类的化学化合物,其特点是两只环;该化合物的特点是一个碳箱胺功能组,其潜力是生物活性分子;甲基和氧化物组的存在表明,它可能具有独特的反应性和溶性;典型的,二衍生物以其在协调化学中的应用而闻名,作为金属离子的皮条和药用化学中的衍生物,它们可能在那里展示各种生物活动;该复合物的结构特征表明它可能参加碳箱酰胺组的氢结缘,影响其在生物系统中的相互作用;此外,二氢形式表明,该物质可能存在于一个减少的状态中,可能影响其稳定性和再活动性.总体而言,2-甲基-六氧-1,6-二水-3-三甲基-三丁基-五-丙烯基氨基氨胺是进一步研究合成化学和药剂的复合物.
- 英文名称2-Methyl-6-Oxo-1,6-Dihydro-[3,4'-Bipyridine]-5-Carboxamide
- 中文名称米力农杂质A
- IUPAC名称2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide
- 其它别名Milrinone Impurit ⅰ：1,6-Dihydro-2-Methyl-6-Oxo(3,4'-Bipyridine)-5-Carboxamide; Milrinone Impurity ⅰ; Milrinone Usp Related Compound A; Milrinone Related Compound A (50 Mg) (1,6-Dihydro-2-Methyl-6-Oxo(3,4'-Bipyridine)-5-Car-Boxamide); Milrinone Amide (Milrinone Impurity); 2-Methyl-6-Oxo-1,6-Dihydro-3,4'-Bipyridine-5-Carboxamide; 1,6-Dihydro-2-Methyl-6-Oxo-[3,4']Bipyridin-5-Ylcarboxylic Acid Amide; Milrinone Amide
- CAS编号80047-24-1
- MFCD编号:MFCD09800601
- FDA UNII编号:75E39HK2X2
- 分子式:C12H11N3O2分子量:229.24
- 产品CID: 1794502
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
CAS号78415-72-2 米力农 | CAS号108-89-4 4-甲基吡啶 | CAS号6304-16-1 (4-吡啶基)丙酮 | CAS号78504-61-7 4-(Dimethylamin...合成工艺路线路线简述
- 78415-72-2 = 80047-24-1
反应条件:1.1 Reagents: Sulfuric Acid; 15 Min,Rt -> 120 °C1.2 Reagents: Ammonium Hydroxide Solvents: Water; Ph 10
标题:Synthesis And Profiling Of A 3-Aminopyridin-2-One-Based Kinase Targeted Fragment Library: Identification Of 3-Amino-5-(Pyridin-4-Yl)Pyridin-2(1H)-One Scaffold For Monopolar Spindle 1 (Mps1) And Aurora Kinases Inhibition
作者:Fearon,Daren; Westwood,Isaac M.; Van Montfort,Rob L. M.; Bayliss,Richard; Jones,Keith; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2018 卷标:26(11) 页码:3021-3029]
129090-34-2 = 80047-24-1
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Ammonia
标题:Preparation Of 5-Aryl-1,2-Dihydropyrid-2-Ones As Cardiotonics
参考文献:German Democratic Republic]
78415-72-2 = 80047-24-1
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 30 Min,100 °C; 100 °C -> 0 °C1.2 Reagents: Water1.3 Reagents: Ammonium Hydroxide Solvents: Water; Ph 10
标题:Purification Of 1,6-Dihydro-2-Methyl-6-Oxo[3,4'-Bipyridine]-5-Carbonitrile (Milrinone) And Synthesis Of Its Usp Impurity A [i.E.,1,6-Dihydro-2-Methyl-6-Oxo-[3,4'-Bipyridine]-5-Carboxamide]
作者:Dai,Xuyong; Guo,Peng; Li,Liwei
参考文献:Zhongguo Yaoxue Zazhi (Beijing 日期:2007 卷标:42(18) 页码:1436-1437]
78415-72-2 = 80047-24-1
反应条件:1.1 Reagents: Sulfuric Acid
标题:Bipyridine Cardiotonics: The Three-Dimensional Structures Of Amrinone And Milrinone
作者:Robertson,David W.; Beedle,E. E.; Swartzendruber,John K.; Jones,Noel D.; Elzey,T. K.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1986 卷标:29(5) 页码:635-40
📜米力农置于硫酸体系中,化学反应 0.25H,以72%的收率获得产物米力农杂质a
参考文献:Synthesis And Profiling Of A 3-Aminopyridin-2-One-Based Kinase Targeted Fragment Library: Identification Of 3-Amino-5-(Pyridin-4-yl)Pyridin-2(1H)-One Scaffold For Monopolar Spindle 1 (Mps1) And Aurora Kinases Inhibition
标题:Synthesis And Profiling Of A 3-Aminopyridin-2-One-Based Kinase Targeted Fragment Library: Identification Of 3-Amino-5-(Pyridin-4-yl)Pyridin-2(1H)-One Scaffold For Monopolar Spindle 1 (Mps1) And Aurora Kinases Inhibition
摘要:Screening A 3-Aminopyridin-2-One Based Fragment Library Against A 26-Kinase Panel Representative Of The Human Kinome Identified 3-Amino 5 (1-Methyl-1H-Pyrazol-4-yl)Pyridin-2(1H)-One (2) And 3-Amino-5(Pyridin-4-yl)Pyridin-2(1H)-One (3) As Ligand Efficient Inhibitors Of The Mitotic Kinase Monopolar Spindle 1 (Mps1) And The Aurora Kinase Family. These Kinases Are Well Recognised As Attractive Targets For Therapeutic Intervention For Treating Cancer. Elucidation Of The Binding Mode Of These Fragments And Their Analogues Has Been Carried Out By X-Ray Crystallography. Structural Studies Have Identified Key Interactions With A Conserved Lysine Residue And Have Highlighted Potential Regions Of Mps1 Which Could Be Targeted To Improve Activity And Selectivity. (C) 2018 The Authors. Published By Elsevier Ltd.
DOI:10.1016/j.Bmc.2018.04.033
海关参考信息
- 2912110000-甲醛
2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-3683014-A
优先权日:1970-10-14
标题:Derivatives of 2-amino-3-sulfopropionic acid
发明人：YANG MEILING T
权利人:ETHYL CORP
摘要:To obviate eutrophication of water, non-phosphorus detergent builders are provided. These are the water-soluble salts of 2-(N, N-di-(carboxymethyl))amino-3-sulfopropionic acid (e.g., the tetrasodium salt thereof). Conventional detergent actives may be used with these builders. Synthesis of the builders is described.
专利号:US-3637511-A
优先权日:1969-05-19
标题:Detergent formulations
发明人：YANG MEILING T
权利人:ETHYL CORP
摘要:To obviate eutrophication of water, nonphosphorus detergent builders are provided. These are the water-soluble salts of N,N,di(carboxymethyl)-aspartic acid (e.g., the tetrasodium salt thereof). Conventional detergent actives may be used with these builders. Synthesis of the builders is described.
专利号:CN-108329445-A
优先权日:2017-01-20
标题:A kind of phenolic resin esterified benzene sulfonate and its synthesis method, hydrophilic plate for printing and its application, and printing plate
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合成参考文献
参考文献:10.1016/j.bmc.2018.04.033
摘要:Fearon D, Westwood IM, van Montfort RLM, Bayliss R, Jones K, Bavetsias V. Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorganic & Medicinal Chemistry. 2018 Jul;26(11):3021–9. doi: 10.1016/j.bmc.2018.04.033.
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