CAS: 695-96-5; 2-Bromo-4-Chlorophenol

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CAS号17005-59-3 4-ClC6H4OSiMe3 | CAS号106-48-9 对氯苯酚 | CAS号95-56-7 2-溴苯酚 | CAS号121767-82-6 2-bromo-4-chlor... | CAS号5324-13-0 2,6-二溴对氯苯酚 | CAS号60633-25-2 2-溴-4-氯苯甲醚 | CAS号376592-93-7 3'-氨基-2'-羟基联苯基-3-甲酸 | CAS号376592-58-4 5'-氯-3'-硝基-2'-羟... | CAS号2212-05-7 4-氯苯基缩水甘油醚 | CAS号27983-04-6 1-(3-溴丙氧基)-4-氯苯 | CAS号612832-83-4 2-苄氧基-5-氯苯硼酸 | CAS号15969-10-5 2-溴-4-氯-6-硝基苯酚 | CAS号13589-72-5 5-氯-2-羟基苯甲腈 | CAS号13659-24-0 3-溴-4-氯苯酚 | CAS号286836-08-6 2-(2-bromo-4-ch...

对氯苯酚置于硫酸,N-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 2.08H,以92%的收率获得产物2-溴-4-氯苯酚
参考文献:使用 N-溴代琥珀酰亚胺对苯酚衍生物进行方便有效的 H2So4 促进区域选择性单溴化
标题:使用 N-溴代琥珀酰亚胺对苯酚衍生物进行方便有效的 H2So4 促进区域选择性单溴化
摘要:摘要 开发了一种方便,快速的 H2So4 促进的 N-溴代琥珀酰亚胺区域选择性单溴化反应.以非常好至极好的收率和高选择性获得了所需的对位单溴化或邻位单溴化的苯酚衍生物产物.在 H2So4 存在下,也分别使用 N-氯代琥珀酰亚胺和 N-碘代琥珀酰亚胺实现了区域选择性氯化和碘化.图形概要
DOI:10.1080/00397911.2019.1711415

专利信息

专利号:US-12435042-B2
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof
发明人：STABILE PAOLO; SEMERARO FLORIANA
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5′-Chloro-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5231198-A
优先权日:1992-07-06
标题:Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols
发明人：POWERS MATTEW R; GOLEC FREDERICK A
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT 3 compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure cishexahydrodibenzofuran compounds including at least two chiral fused ring centers which comprises the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma, i.e. 2', carbon atom of a 2-[(2'-leaving group)cycloalkyl]phenol.

专利号:WO-2013049605-A1
优先权日:2011-09-28
标题 :Processes for the preparation of an intermediate in the synthesis of eltrombopag
发明人：AVDAGIC AMIR; BARAN PHIL S
权利人:ASSIA CHEM IND LTD; TEVA PHARMACEUTICAL USA INC
摘要:3'-Amino-2'-hydroxybiphenyl-3-carboxylic acid (BPCA) and related compounds have been prepared using compounds such as: wherein R 1 is -H, -Cl or -F; R 2 is -Br or -I; and R 3 is -H or -N0 2 . BPCA is useful, for example, in the preparation of Eltrombopag.

专利号:US-2022298116-A1
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof

专利号:WO-9401428-A1
优先权日:1992-07-06
标 题 :Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols