CAS: 62265-68-3; 1-(2,2-Dichloroacetyl)-1,2,3,4-Tetrahydroquinolin-6-Yl Furan-2-Carboxylate

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1-(二氯乙酰基)-1,2,3,4-四氢喹啉-6-醇 1-Dichloroacetyl-1,2,3,4-Tetrahydro-Quinolin-6-Ol 62265-67-2

📜6-羟基-1,2,3,4-四氢喹啉置于溶剂黄146,三乙胺体系中,用 甲醇,正己烷,氯仿,乙酸乙酯 作为反应溶剂,化学反应生成 喹法米特
参考文献:1-(Halogenated-Acetyl)-1,2,3,4-Tetrahydro-6-Quinolinols And Esters
标题:1-(Halogenated-Acetyl)-1,2,3,4-Tetrahydro-6-Quinolinols And Esters
摘要:具有抗阿米巴作用的化合物是1-(Ac.Sub.1)-5-R-6-(Ac.Sub.2 O)-1,2,3,4-四氢喹啉(i),其中ac.Sub.1是卤代乙酰基,二卤代乙酰基或三卤代乙酰基,卤是氯或溴,R是氢,氯或溴,Ac.Sub.2是氢,Ac.Sub.1,具有一至十六个碳原子的脂肪酰基,苯甲酰基,2(或3)-硫代苯甲酰基,2(或3)-呋喃酰基或n-(较低烷基)氨基甲酰基.所述化合物的制备方法包括:通过将1,2,3,4-四氢-6-喹啉酚与式ac.Sub.1-卤素的酰卤反应,制备具有式i的1-(Ac.Sub.1)-1,2,3,4-四氢-6-喹啉酚,其中r和ac.Sub.2分别为氢,Ac.Sub.1如式i中定义,卤素为氯或溴;通过将所述1-(Ac.Sub.1)-1,2,3,4-四氢-6-喹啉酚与氯化剂或溴化剂反应,制备相应的1-(Ac.Sub.1)-5-氯(或溴)-1,2,3,4-四氢-6-喹啉酚,其中ac.Sub.1如权利要求1中定义;通过将1-(Ac.Sub.1)-5-R-1,2,3,4-四氢-6-喹啉酚与提供ac.Sub.2的酰化剂反应,制备具有式i的1-(Ac.Sub.1)-5-R-1,2,3,4-四氢-6-(Ac.Sub.2 O)喹啉,其中r为氢,氯或溴,Ac.Sub.1如式i中定义,Ac.Sub.2不同于式i中定义的氢.

专利信息

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.