CAS: 591-09-3; Nitro Acetate

📜乙烯酮置于二氯甲烷,硝酸体系中,化学反应生成 硝酸乙酸酐
参考文献:De849405
标题:De849405

专利信息

专利号:US-4427587-A
优先权日:1982-11-10
标 题:Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
发明人：KANEKO TAKUSHI; WONG HENRY S L
权利人:BRISTOL MYERS CO
摘要:A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.

专利号:US-4381400-A
优先权日:1981-02-27
标 题 :Process for the synthesis of isosorbide mononitrates
发明人：EMEURY JEAN-MARIE; WIMMER ERIC
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to the synthesis of isosorbide mononitrates. n The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:WO-2025133577-A1
优先权日:2023-12-18
标题 :Flow synthesis of rdx
发明人：DIDSBURY MATTHEW PAUL; THOMAS SIMON DAVID; MCWHIR NAIL; JONES CHRISTOPHER; JUBB DANIEL; KENNEDY STUART; PAI YAN CHAN ANTONY; ANGELA KA YUNG FONG
权利人:BAE SYSTEMS PLC
摘要:The invention relates to a method for the flow synthesis manufacture of RDX, comprising the steps of i. preparing input flow reagent A comprising greater than 95% concentration nitric acid and NH4NO3 ii. preparing input flow reagent B comprising hexamine dissolved in acetic acid; iii. preparing input flow reagent C, comprising acetic anhydride; iv. causing the input flow reagents A, B and C to enter a flow reactor, v. maintaining the reaction chamber to less than 90°C, vi. causing the input flow reagents to react in the reactor.

专利号:US-6881847-B2
优先权日:2001-02-01
标题:Process for the synthesis and recovery of nitramines
发明人：HIGHSMITH THOMAS K; HANKS JAMI M; VELARDE STEPHEN P; BOTTARO JEFFREY
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate.