CAS: 58743-75-2; 4'-Ethyl-[1,1'-Biphenyl]-4-Carbonitrile

上下游产品

1-bromo-4-(4'-ethylphenyl)benzene copper(I) cyanide 4-bromo-4'-acetylbiphenyl p-ethylphenylmagnesium bromide 4-(4-ethylphenyl)benzoic acid

4'-Vinylbiphenyl-4-Carbonitrile置于1,4-二氧六环,Bis(1,5-Cyclooctadiene)Diiridium(I) Dichloride,1,2-双(二环己基磷基)-乙烷体系中,化学反应 10.0H,以98%的收率获得产物4'-乙基-4-氰基联苯
参考文献:1,4-二恶烷作为氢供体的铱催化烯烃选择性转移加氢
标题:1,4-二恶烷作为氢供体的铱催化烯烃选择性转移加氢
摘要:描述了使用1,4-二恶烷作为氢供体的铱催化的烯烃的转移加氢.1,2-双(二环己基膦基)乙烷(dcype)的使用具有体积大和给电子高的特性,因此具有很高的催化活性.聚苯乙烯交联双膦ps-Dppbz产生了可重复使用的非均相催化剂.这些均质和非均质的方案实现了烯烃在其他可能还原的官能团(例如同一分子中的羰基,硝基,氰基和亚氨基)上的化学选择性转移加氢.
DOI:10.1021/acs.Orglett.9B01989

专利信息

专利号:WO-2009117985-A1
优先权日:2008-06-12
标题 :Pirinixic acid derivatives as prostglandin e2 synthesis inhibitors for treating inflammatory diseases
发明人：WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
权利人:MEDEON PHARMACEUTICALS GMBH; UNIV TUEBINGEN; WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
摘要:The invention relates to pirinixic acid derivatives, especially a-substituted pirinixic acids and pirinixic acid esters, and the structural derivatives thereof with the following structural formula. The pirinixic acid derivatives inhibit the PGE2 synthesis, especially that of the mPGES-1. The invention also relates to the use of said pirinixic acid derivatives for producing a medicament for treating prostaglandin E2-mediated diseases, especially inflammatory diseases, painful and feverish conditions, cardiovascular events and cancerous diseases associated with an increased inducible microsomal prostaglandin E2 synthesis-1 (mPGES-1) activity or increased prostaglandin E2 synthesis.