CAS: 58574-03-1; 4'-Hydroxy-[1,1'-Biphenyl]-4-Carboxylic Acid

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CAS号19812-93-2 氰基联苯酚 | CAS号106-41-2 对溴苯酚 | CAS号14047-29-1 4-羧基苯硼酸 | CAS号725-14-4 4'-甲氧基联苯基-4-羧酸 | CAS号99-76-3 尼泊金甲酯 | CAS号98-83-9 α-甲基苯乙烯 | CAS号108-95-2 苯酚 | CAS号64-18-6 甲酸 | CAS号71151-89-8 4-(Trifluoroace... | CAS号59748-15-1 4-(戊氧基)-4'-联苯羧酸 | CAS号59748-16-2 4-(己氧基)-4’-联苯基羧酸 | CAS号50670-76-3 4'-羟基-4-联苯羧酸乙酯 | CAS号59748-14-0 4-丁氧基-4’-联苯羧酸 | CAS号59748-13-9 4-丙氧基-4’-二苯甲酸 | CAS号69367-32-4 4'-癸氧基联苯-4-羧酸 | CAS号729-17-9 4'-甲氧基-[1,1'-联苯... | CAS号155791-03-0 ethyl 4-(4-hydr... | CAS号59748-18-4 4-正辛氧基联苯-4-甲酸 | CAS号77764-75-1 2'-°Ctyloxybiph...

4-苯基苯甲酸置于cunninghamella Elegans体系中,用 二甲基亚砜 作为反应溶剂,化学反应 72.0H,反应生成 4'-羟基联苯-4-羧酸
参考文献:A Convenient Chemical-Microbial Method For Developing Fluorinated Pharmaceuticals
标题:A Convenient Chemical-Microbial Method For Developing Fluorinated Pharmaceuticals
摘要:大部分药物含有氟元素,在药物开发过程中,选择氟元素的加入位置可能是一个有益的环节.在这里,我们描述了初始实验,旨在开发一种通用方法,选择前药分子上最佳的氟化位置,以提高代谢稳定性.通过含有细胞色素p450的真菌和细菌分别对几种联苯衍生物进行转化,这些细胞色素p450模拟了体内的氧化过程,从而确定了氧化位置.随后,利用适当的铃木-宫浦偶联反应合成了氟化联苯衍生物,将氟原子置于预定微生物氧化的位置;这些氟化联苯衍生物与微生物共培养,并评估了氧化程度.结果显示,联苯-4-羧酸被cunninghamella Elegans完全转化为4'-羟基联苯-4-羧酸,但4'-氟代衍生物保持不变,证明了微生物氧化-化学氟化的概念.2'-氟代和3'-氟代联苯-4-羧酸也能被转化,但速度比未氟化的联苯羧酸衍生物慢.因此,可以通过体外方法确定最容易氧化的位置,然后进行氟化,迭代设计代谢半衰期更长的化合物,无需依赖大量的动物研究.
DOI:10.1039/c2Ob27140K

专利信息

专利号:US-8329854-B2
优先权日:2010-09-27
标题 :Synthesis of tri-component resins
发明人：BIRAU MARIA; ALLEN C GEOFFREY
权利人:BIRAU MARIA; ALLEN C GEOFFREY; XEROX CORP
摘要:A resinous compound of the formulas or a salt thereof, wherein G1 is —X1C(O)OR1, —X2OC(O)R2, or —X2OH; G2 is R4, R12, —C(O)R2, —C(O)X1C(O)OR1, or —C(O)X2OC(O)R2; R1 is an alkyl having from 10 to 80 carbon atoms; R2 is an alkyl having from 2 to 40 carbon atoms; each R3 and R4 is independently hydrogen, alkyl, arylalkyl or alkylaryl; each R5 and each R6 is independently hydrogen or alkyl; X1 and X2 are both a straight or branched alkylene group; t1 is 1 to 20; t2 and t3 is independently 0 to 20; u1 is 1 to 30; u2 and u3 is independently 0 to 30; each R7 and each R8 is independently hydrogen, alkyl, or alkoxyl; each R9 and each R10 is independently hydrogen, alkyl, or alkoxyl; Ar is a substituted or unsubstituted aromatic moiety; p is 1 to 5; q is 1 to 12; A⊖ is selected from the group consisting of Cl−, Br−, I−, HSO4−, HSO3−, CH3SO3−, NO3−, HCOO−, CH3COO−, H2PO4−, SCN−, BF4−, ClO4−, SSO3−, PF6−, and SbCl6−; and J is alkyl, arylalkyl, or alkylaryl.

专利号:US-8137582-B2
优先权日:2007-08-15
标题 :Alkaloid monomers, liquid crystal compositions and polymer networks derived therefrom
发明人：GOLDFINGER MARC B; QI KAI
权利人:GOLDFINGER MARC B; QI KAI; DU PONT
摘要:Disclosed is the chemical synthesis of chiral alkaloid monomers, liquid crystal compositions comprising the chiral alkaloid monomers, and polymerization of the liquid crystal compositions to provide polymer networks with useful cholesteric optical properties and stability.

专利号:US-6069149-A
优先权日:1997-01-09
标 题:Amide derivatives and intermediates for the synthesis thereof
发明人：NANBA RYOUICHI; IIZUKA TAKAO; ISHII TAKEO
权利人:TERUMO CORP
摘要:PCT No. PCT/JP98/00005 Sec. 371 Date Nov. 23, 1998 Sec. 102(e) Date Nov. 23, 1998 PCT Filed Jan. 6, 1998 PCT Pub. No. WO98/30562 PCT Pub. Date Jul. 16, 1998Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon ( alpha , gamma )-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2: each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3: hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.

专利号:JP-2012072137-A
优先权日:2010-09-27
标 题 :Synthesis of three-component resin

专利号:US-2012077953-A1
优先权日:2010-09-27
标 题:Synthesis of tri-component resins

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.