CAS: 5604-46-6; 2-Amino-4,6-Dichloropyrimidine-5-Carbaldehyde

相似化合物

1277179-33-5 7153-13-1 20090-58-8

上下游产品

CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号56-09-7 2-氨基-4,6-二羟基嘧啶 | CAS号847560-46-7 2-氨基-4-氯噻吩并[2,3... | CAS号850554-82-4 4,6-Dichloro-5-... | CAS号100644-70-0 8-AZA-7-DEAZA-2... | CAS号100644-65-3 4-氯-6-氨基-1H-吡唑并... | CAS号850554-81-3 (2-Amino-4,6-di... | CAS号85840-23-9 2-氨基-4-氯-6-氧代-1... | CAS号99979-82-5 6-Amino-1,2-dih...

2-氨基-4,6-二羟基嘧啶 反应生成 2-氨基-4,6-二氯嘧啶-5-甲醛
参考文献:Adenosine A2A Receptor Antagonists
标题:Adenosine A2A Receptor Antagonists
摘要:具有结构式i或其药物可接受的盐,其中r是可选取代的苯基,环烯基或杂环基;x是烷基或-C(o)ch2-;y是-N(r2)ch2Ch2N(r3)-,-och2Ch2N(r2)-,-O-,-S-,-Ch2S-,-(ch2)2-Nh-或可选取代的m和n为2-3,Q为氮或可选取代的碳;z是可选取代的苯基,苯基烷基或杂环基,二苯甲基,R6-C(o)-,R6-So2-,R6-oc(o)-,R7-N(r8)-C(o)-,R7-N(r8)-C(S)-,苯基-Ch(oh)-或苯基-C(═nor2)-;或当q为ch时,为苯胺基或吡啶基氨基;或z和y一起为取代的哌啶基或取代的苯基;以及r2,R3,R6,R7和r8在说明书中所定义的,它们在单独使用或与其他治疗帕金森病的药物联合使用中用于治疗帕金森病的用途以及包含它们的制药组合物;还披露了用于制备结构式i化合物的有用中间体的制备过程.

专利信息

专利号:US-9994526-B2
优先权日:2011-04-04
标 题 :Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate
发明人：STIVANELLO MARIANO; HUBER FLORIAN ANTON MARTIN; RICCI ANTONIO
权利人:LUNDBECK PHARMACEUTICALS ITALY S P A
摘要:Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-6048975-A
优先权日:1991-09-12
标 题:Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:A process for the chemical synthesis of oligonucleotides n Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-5945524-A
优先权日:1990-09-14
标 题 :Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-11613514-B2
优先权日:2016-03-25
标题:Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
发明人：THOMAS CRAIG; ZARATE CARLOS; MOADDEL RUIN; GOULD TODD; ZANOS PANOS; MORRIS PATRICK
权利人:US HEALTH; UNIV MARYLAND
摘要:The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.