CAS: 3288-04-8; 2-Methoxyphenylisothiocyanate

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(2-Methoxy-Phenyl)-Dithiocarbamic Acid ; Compound With Triethylamine置于氯甲酸甲酯体系中,用 氯仿 作为反应溶剂,化学反应 5.0H,反应生成 异氰酸2-甲氧苯酯
参考文献:Synthesis And Biological Evaluation Of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives As Trpv1 Antagonists
标题:Synthesis And Biological Evaluation Of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives As Trpv1 Antagonists
摘要:Trpv1受体是一个重要的镇痛靶点,其拮抗剂有望通过直接阻断受体来预防疼痛感知.在本文中,我们设计并合成了8种二氢异喹啉-2(1H)-硫代酰胺衍生物作为trpv1拮抗剂,并对苯环进行了不同的取代基修饰.初步的生物测试表明,这些新化合物显示出trpv1拮抗活性,并具有不同的镇痛效果,其中一些有望成为镇痛药物.
DOI:10.2174/157018010790945797

专利信息

专利号:US-5585487-A
优先权日:1995-05-26
标题:Method for the preparation of β-thiolactam compound
发明人：OISHI AKIHIRO; TAGUCHI YOICHI; SHIBUYA ISAO; TSUCHIYA TOHRU
权利人:AGENCY IND SCIENCE TECHN
摘要:Disclosed is a method for the preparation of a beta -thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R-NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.