CAS: 31928-47-9; 4-Bromo-2-Chloro-1-Iodobenzene

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CAS号108-37-2 1-溴-3-氯苯 | CAS号158435-41-7 4-溴-2-氯苯甲醛 | CAS号606144-02-9 5-(4-溴苯氨基)-4-氟-... | CAS号606144-04-1 5-((4-溴-2-氯苯基)氨...

4-溴-2-氯苯胺置于盐酸,Sodium Nitrite,Potassium Iodide体系中,用 水 作为反应溶剂,化学反应 4.0H,以75%的收率获得产物4-溴-2-氯碘苯
参考文献:由c 序列模合成苯并[9,10-C]噻吩 H活化,铃木交叉偶联和光环化反应
标题:由c 序列模合成苯并[9,10-C]噻吩 H活化,铃木交叉偶联和光环化反应
摘要:总共合成了15个不同的3,4-二芳基噻吩,它们在一个芳基取代基的邻位带有一个氯原子.通过氧化交叉偶联反应引入一个芳基,该反应涉及噻吩核的c4(3)处的ch活化.在大多数情况下,另一个芳基是通过铃木交叉偶联反应引入的,该反应是氧化交叉偶联步骤的后续步骤.3,4-二芳基噻吩的光环化反应是在苯和乙腈的混合溶剂中(50:50 V / V)在λ = 254 Nm处进行的,标题化合物的收率为60-82%.在邻位确定光环化的选择性氯取代的芳基环由氯取代基的位置决定.在另一个环上,观测到一个单一的区域异构体的苯基和对位取代的苯基.对于2-萘基和邻位取代的苯环,人们明显倾向于主要的区域异构体,而苯环中的间位取代则导致5和7位取代的菲咯啉的比例约为1:1 [9,10] [C]噻吩.从机理上讲,光环化很可能发生在光化学允许的,旋转的[(4N + 2)π]过程中,并伴随着hcl的消除.显示了两个菲咯啉[9,10-
DOI:10.1002/chem.201402765

专利信息

专利号:US-RE49222-E
优先权日:2013-10-02
标题 :Fluorine-containing complex compound, and production method for fluorine-containing organic compound employing same
发明人：ADACHI KENJI; SHIBANUMA TAKASHI; NAGAI TAKABUMI; OGOSHI SENSUKE; OHASHI MASATO
权利人:DAIKIN IND LTD; UNIV OSAKA
摘要:An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF 2 —CF 2 —). The present invention provides a fluorine-containing complex compound includingn a fluorine-containing organic metal compound represented by formula (1a):n nR 1 —CF 2 —CF 2 -M 1   (1a)n nwherein M 1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R 1 represents an organic group, andn at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.

专利号:CN-108129478-B
优先权日:2018-01-12
标题:A kind of copper process for catalytic synthesis of organic sulphones and application

专利号:CN-108129478-A
优先权日:2018-01-12
标 题:Copper-catalyzed synthesis method and application of a kind of organic sulfone compound

专利号:EP-2118111-B1
优先权日:2007-02-06
标题 :2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer
发明人：BENNETT MICHAEL JOHN; ZEHNDER LUKE RAYMOND; NINKOVIC SACHA; KUNG PEI-PEI; MENG JERRY JIALUN; HUANG BUWEN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.