CAS: 2770-01-6; 4-Chloro-1H-Imidazo[4,5-C]Pyridine

相似化合物

2589-12-0 2589-11-9 579486-60-5

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1H-咪唑[4,5-C]吡啶 Imidazo<4,5-C>Pyridine 272-97-9

📜2-氯吡啶-N-氧化物置于盐酸,Tin(II) Chloride Dihdyrate,硫酸,硝酸,铁粉体系中,用 乙醇,水 用作溶剂,化学反应生成4-氯咪唑[4,5-C]吡啶
参考文献:设计和合成嘌呤类似物作为fcγb(一种无处不在的真菌核碱基转运蛋白)的高度特异性配体
标题:设计和合成嘌呤类似物作为fcγb(一种无处不在的真菌核碱基转运蛋白)的高度特异性配体
摘要:在我们对真菌嘌呤转运蛋白的研究过程中,基于嘌呤底物与构巢曲霉fcγb载体的相互作用,合理地设计了许多新的3-脱氮嘌呤类似物,并按照有效的合成程序进行了合成.已经发现某些衍生物特异性抑制fcγb介导的[ 3 H]-腺嘌呤摄取.已经进行了分子模拟,表明所有活性化合物都通过与asn163形成氢键与fcyb相互作用,而在3-Deazaadenine的9和n 6位插入疏水片段增强了抑制作用.
Doi:10.1016/j.Bmc.2016.09.055

专利信息

专利号:US-4347315-A
优先权日:1980-04-25
标 题 :Synthesis of ribosides using bacterial phosphorylase
发明人：KRENITSKY THOMAS A; RIDEOUT JANET L
权利人:BURROUGHS WELLCOME CO
摘要:4-Substituted-3-deazapurine ribosides are prepared by the enzymatically catalyzed reaction of 4-substituted-3-deazapurine with a ribose donor.

专利号:EP-0038568-B1
优先权日:1980-04-23
标题 :Synthesis of deazapurine nucleosides
摘要:A method for the preparation of 4-substituted-1- beta -D-ribofuranosyl-1H-imidazo- [4,5-c)-pyridines by enzymatic ribosylation of the corresponding 4-substituted-1H-imidazo-[4,5-c]-pyridine is disclosed. In particular the preparation of 4-amino-1- beta -D-ribofuranosyl-1H-imidazo-[4,5-c]-pyridine (3-deazadenosine) is described.

专利号:US-5639867-A
优先权日:1993-09-17
标 题 :TTTr as protective group in nucleotide synthesis
发明人：BRILL WOLFGANG K-D
权利人:CIBA GEIGY CORP
摘要:The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4'-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a process for the preparation of oligonucleotides, and to the use of said protected nucleosides, nucleotides and oligonucleotides.

专利号:EP-0038568-A1
优先权日:1980-04-23
标题:Synthesis of deazapurine nucleosides

专利号:CA-1162155-A
优先权日:1980-04-23
标 题:Synthesis of deazapurine nucleosides

专利号:US-2009270431-A1
优先权日:2005-10-19
标 题 :Cyclopentenol Nucleoside Compounds Intermediates for their Synthesis and Methods of Treating Viral Infections
发明人：CHU DAVID C K; CHO JONG HYUN; KIM HYO-JOONG
权利人:UNIV GEORGIA RES FOUND
摘要:The present invention relates to compounds according to the structure (I), Where B is formula (Ia), formula (Ib) or formula (Ic); A is H, OR 2 or halogen (F, Cl, Br, I, preferably F or Br, more preferably F); A′ is H, OR2 or halogen (F, Cl, Br, I, preferably F or Br, more preferably F); A″ is H or OR 1 , with the proviso that when A′ is OR, A is H; and when A is OR 2 , A′ is H; X is C—R 3 or N; Y is C—R 3 or N; preferably X or Y is N and X and Y are not both simultaneously N; R 3 is H or C 1 -C 3 alkyl; D is H or NHR 2 ; E is absent or H; G is O or NHR 2 ; J is N or C—R 4 ; K is N or C—H; R 4 is H, halogen (F, Cl, Br, I), CN, —C(â•?O)NH 2 , NH 2 , NO 2 , —Câ•?C—H (cis or trans) or —C≡C—H; R a is H or CH 3 ; Each R 1 is independently H, an acyl group, a C 1 -C 20 alkyl or ether group, a phosphate, diphosphate, triphosphate, phosphodiester group; Each R 2 is independently H, an acyl group, a C 1 -C 20 alkyl or ether group;and Pharmaceutically acceptable salts, solvates or polymorphs thereof.