专利号:US-4713383-A 优先权日:1984-10-01 标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses 发明人:FRANCIS JOHN E; GELOTTE KARL O 权利人:CIBA GEIGY CORP 摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.
专利号:US-6429311-B2 优先权日:1997-12-15 标 题:Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof 发明人:GAO YUN 权利人:SEPRACOR INC 摘要:The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis of 3-hydroxy- and 3-amino-4 (1H)-quinazolinones via the reaction of an appropriate 2-aminobenzamide compound with a carboxylic acid or acyl halide at ambient temperature performed on a solid support or in solution.
专利号:US-9943809-B2 优先权日:2014-02-27 标题 :Solvent resistant thin film composite membrane and its preparation 发明人:DOM ELKE; HERMANS SANNE; KOECKELBERGHS GUY; VANKELECOM IVO 权利人:KATHOLIEKE UNIV LEUVEN KU LEUVEN RESEARCH & DEVELOPMENT; UNIV LEUVEN KATH 摘要:The present invention relates to improved methods for synthesis of thin film composite membranes by interfacial polymerization. More in particular, the method of the present invention comprises the impregnation of an ultrafiltration porous support membrane with an aqueous solution containing a polyfunctional nucleophilic monomer, and contacting the impregnated support membrane with a second largely water-immiscible solvent containing a polyfunctional epoxide monomer.
专利号:CN-107698599-A 优先权日:2017-09-26 标题:Synthesis of pyridazino[6,1‑b]pyrrolo[1,2‑a]quinazolinone derivatives
专利号:CN-115785133-A 优先权日:2022-12-02 标题:In-situ synthesis method and application of quinazolinone Schiff base dysprosium complex
参考标题:Synthesis And Properties Of 1,2-Dihydro-4(3H)-Quinazolinones 作者:D. S. Khachatryan,S. K. Belus,V. A. Misyurin,M. A. Baryshnikova,A. V. Kolotaev,K. R. Matevosyan |发布日期:2017.6 摘要:We Modified The Preparative-Scale Method For The Synthesis Of 2-Aryl 1,2-Dihydro-4(3H)-Quinazolinone Derivatives Obtained In High Yields By The Reaction Of New And Commercially Available Aromatic Aldehydes With Anthranilic Acid Amides. A Series Of Quinazolinone Derivatives Possessing Anticancer And Antiparasitic Activities, As Well As Capable Of Preventing The Progress Of Neurodegenerative Diseases
合成参考文献
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