CAS: 1878-29-1; Ethyl 3-(3,4,5-Trimethoxyphenyl)Acrylate

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CAS号86-81-7 3,4,5-三甲氧基苯甲醛 | CAS号1099-45-2 乙基(三苯基膦)乙酸酯 | CAS号867-13-0 磷酰基乙酸三乙酯 | CAS号4521-61-3 3,4,5-三甲氧基苯甲酰氯 | CAS号140-88-5 丙烯酸乙酯 | CAS号20329-98-0 (E)-3,4,5-三甲氧基肉桂酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号64-17-5 乙醇 | CAS号118-41-2 3,4,5-三甲氧基苯甲酸 | CAS号141-82-2 丙二酸 | CAS号20069-09-4 荜茇酰胺 | CAS号70311-20-5 3-(3,4,5-三甲氧基苯基)丙酸乙酯 | CAS号56438-71-2 5-ethyl-1,2,3-t... | CAS号13400-02-7 1,2,3-三甲氧基-5-乙烯基苯 | CAS号1703-35-1 (E)-1-pyrrolidi... | CAS号1504-56-9 3-(3,4,5-trimet... | CAS号20329-98-0 (E)-3,4,5-三甲氧基肉桂酸 | CAS号20329-96-8 3,4,5-三甲基肉桂酸甲酯 | CAS号1703-36-2 (E)-1-(4-methyl... | CAS号70311-23-8 2-[2-[(5-methyl...

📜3,4,5-三甲氧基苯甲醛置于哌啶,吡啶,氯化亚砜体系中,化学反应生成3,4,5-三甲氧基肉桂酸乙酯
参考文献:Synthesis And Biological Evaluation Of 4-Arylcoumarins As Potential Anti-Alzheimer's Disease Agents
标题:Synthesis And Biological Evaluation Of 4-Arylcoumarins As Potential Anti-Alzheimer's Disease Agents
摘要:Alzheimer'S Disease (Ad) Is A Progressive Neurological Degenerative Disease That Has Complex Pathogenesis. A Variety Of Studies In Humans Indicate That Several Enzymes Inhibitors Can Be Useful In The Treatment Of Ad,Including Acetylcholinesterase (Ache),Butyrylcholinesterase (Buche) And Monoamine Oxidase (Mao). Various Substituted 4-Arylcoumarin Derivatives Were Synthesised,And Their Activity In Vitro Were Investigated,Including Ache/buche Inhibitory Activity,Mao Inhibitory Activity,And Antioxidant Activity. Most Of The Compounds Were Found To Exhibit High Inhibitory Activity,And Individual Compounds Have Extremely Excellent Activities. Therefore 4-Arylcoumarins Provides An Idea For Drugs Design For The Development Of Therapeutic Or Preventive Agents For Ad.
Doi:10.1016/j.Bmcl.2019.126900

专利信息

专利号:WO-2012107934-A1
优先权日:2011-02-10
标题 :Flinderole analogues and process for synthesis thereof
发明人：DETHE DATTATRAYA HANUMANT; ERANDE ROHAN DILIPRAO; RANJAN ALOK
权利人:COUNCIL SCIENT IND RES; DETHE DATTATRAYA HANUMANT; ERANDE ROHAN DILIPRAO; RANJAN ALOK
摘要:The present invention discloses flinderole compounds/analogues of formula I and to a process for the preparation of same, comprising stereo- and regioselective [3+2] cycloaddition reaction of a tertiary alcohol (1a') and a sulphonated diene (1b') in presence of Lewis acid selected from Cu(OTf)2 or BF 3 OEt 2 and a non-polar solvent at room temperature. The flinderole compounds /analogues of the instant invention and prepared by the process described therein is represented by the general formula I,(The formula I should be inserted here) wherein R1-R4 are described herein in the specification.