CAS: 1655-54-5; (S)-2-((2,4-Dinitrophenyl)Amino)-3-Phenylpropanoic Acid

相似化合物

52033-70-2 100870-32-4 100716-41-4

上下游产品

CAS号63-91-2 L-苯丙氨酸 | CAS号70-34-8 2,4-二硝基氟苯 | CAS号584-48-5 1-溴-2,4-二硝基苯 | CAS号97-00-7 1-氯-2,4-二硝基苯 | CAS号99-65-0 间二硝基苯 | CAS号150-30-1 DL-苯丙氨酸 | CAS号2566-30-5 N-甲基-L-苯丙氨酸

📜L-苯丙氨酸,2,4-二硝基氟苯置于碳酸氢钠体系中,用 水 用作溶剂,化学反应 0.01H,以93%的收率获得n-2,4-二硝基苯-L-苯丙氨酸
参考文献:聚焦微波辐射下芳基卤化物与氨基酸的高效亲核取代反应
标题:聚焦微波辐射下芳基卤化物与氨基酸的高效亲核取代反应
摘要:在微波辐射下,在40 S内完成了2,4-二硝基氟苯与氨基酸的亲核取代反应,收率高达93%,远远优于传统加热条件下的收率.
Doi:10.1016/s0040-4020(00)00739-0

专利信息

专利号:US-3996268-A
优先权日:1974-09-03
标题:Cross-linking reagent for insulin synthesis
发明人：CARPENTER FREDERICK H; BUSSE WOLF-DIETER
权利人:UNIV CALIFORNIA
摘要:Carbonyl-bis (L-methionine p-nitrophenyl ester) and its analogues are useful reagents for the intermolecular cross-linking of two chain peptide molecules such as occur in the hormone insulin. The cross-linking occurs across amino groups at preferred positions in the two peptide chains to fix the relative spacial position of the peptide chains and permit the oxidative formation of necessary disulfide bridges between the chains in high yields. The reagent is then removed from the linked chains to yield the insulin molecule. A method for preparation of the reagent is disclosed. Further, a procedure is disclosed by which the cross-linking reagent is used to specifically block certain amino groups on insulin to yield a cross-linked insulin which in turn is used to prepare isotopically labeled insulin and insulin analogues.