CAS: 1490-25-1; Methyl 4-Chloro-4-Oxobutanoate

相似化合物

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上下游产品

CAS号3878-55-5 丁二酸单甲酯 | CAS号108-30-5 丁二酸酐 | CAS号106-65-0 琥珀酸二甲酯 | CAS号105234-41-1 methyl 4-[(2-ca... | CAS号50835-77-3 3-异氰酰基丙酸甲酯 | CAS号3153-44-4 3-(4-甲氧基苯甲酰基)丙酸 | CAS号5802-82-4 蜡酸甲酯 | CAS号14563-40-7 Benzenebutanoic... | CAS号624-45-3 乙酰丙酸甲酯 | CAS号119-61-9 二苯甲酮 | CAS号119-53-9 2-羟基-2-苯基苯乙酮 | CAS号120568-24-3 6-carboethoxy-1... | CAS号2420-38-4 4-Hydroxy°Ctade...

丁二酸单甲酯置于氯化亚砜体系中,化学反应生成丁二酸单甲酯酰氯
参考文献:Synthesis Of Quinones Having Carboxy-And Hydroxy-Alkyl Side Chains,And Their Effects On Rat-Liver Lysosomal Membrane.
标题:Synthesis Of Quinones Having Carboxy-And Hydroxy-Alkyl Side Chains,And Their Effects On Rat-Liver Lysosomal Membrane.
摘要:为了研究辅酶q,α-生育酚和叶绿醌(ia,B,C,Iia,B,C)的代谢产物结构活性关系,将3-羧基-2-丁烯基(iiia,B,C),6-羟基-3-甲基-2-己烯基(iva,B,C),4-羟基-3-甲基丁基(va,B),4-羟基-3-甲基-2-丁烯基(vib,C),ω-羧基烷基(viia,B,C)和ω-羟基烷基(viiia,B)侧链引入到2,3-二甲氧基-5-甲基-1,4-苯醌和2,3,5-三甲基-1,4-苯醌的6-位以及2-甲基-1,4-萘醌的3-位.研究了这些醌类化合物对大鼠肝脏溶酶体膜稳定性和牛心磷酸二酯酶活性的影响.苯醌衍生物(viia,B)的这些活性之间观测到了非常好的相关性.
Doi:10.1248/cpb.30.2797

专利信息

专利号:US-2010159540-A1
优先权日:2007-03-26
标题:Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
发明人：RODRIGUEZ ANA; SPUR BERND
权利人:RODRIGUEZ ANA; SPUR BERND
摘要:Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.

专利号:US-4374979-A
优先权日:1981-04-27
标 题:Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
发明人：MITSCHER LESTER A
权利人:UNIV KANSAS ENDOWMENT ASS
摘要:A regiospecific synthesis for anthracyclinones asymmetric is disclosed. The synthesis is based upon a regiospecific bromination of the C-7 position of the alpha -tetralone which after transposing the keto group to the beta -position and reaction with an organo-lithium compound is condensed with a phthalate ester.

专利号:US-5216005-A
优先权日:1989-03-15
标题:Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-5173482-A
优先权日:1989-03-15
标 题 :Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-4895872-A
优先权日:1989-03-15
标题:Immunosupressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPAPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.