CAS: 125926-17-2; Sarpogrelate

该化合物是一种选择性的血清素受体激素受体对抗剂,具体针对5-HT2A子型,在小板块聚集和血管滑动肌肉收缩方面起着关键作用,其主要治疗用途是作为抗板剂,抑制Thymbus的形成,改善外围循环.Sarpogrelate在临床上被用于管理动脉隔离疾病和糖尿病...

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    专利号:US-8420850-B2
    优先权日:2010-05-14
    标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
    发明人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
    权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
    摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

    专利号:US-2012282255-A1
    优先权日:2011-04-07
    标题 :Methods and compositions for the treatment of alcoholism and alcohol dependence
    发明人:PLUCINSKI GREG
    权利人:PLUCINSKI GREG
    摘要:The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:US-2012059117-A1
    优先权日:2010-05-14
    标 题 :Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers

    专利号:WO-2011141341-A1
    优先权日:2010-05-14
    标题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers

    专利号:EP-2569015-A1
    优先权日:2010-05-14
    标题 :Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers

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    合成参考文献


    参考文献:10.1253/circj.72.633
    摘要:Bir SC, Fujita M, Marui A, Hirose K, Arai Y, Sakaguchi H, Huang Y, Esaki J, Ikeda T, Tabata Y, Komeda M. New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia. Circ J. 2008 Apr;72(4):633–40. doi: 10.1253/circj.72.633.
    参考文献:10.1007/s00330-019-06306-5
    摘要:Jeong MJ, Kwon H, Ko GY, Gwon DI, Kim MJ, Han Y, Kwon TW, Cho YP. New predictors of aneurysm sac behavior after endovascular aortic aneurysm repair. Eur Radiol. 2019 Dec;29(12):6591–9. doi: 10.1007/s00330-019-06306-5.
    参考文献:10.1186/s12902-020-00605-5
    摘要:Yoo H, Choo E, Lee S. Study of hospitalization and mortality in Korean diabetic patients using the diabetes complications severity index. BMC Endocrine Disorders. 2020 Aug 10;20(1):122. doi: 10.1186/s12902-020-00605-5.
    参考文献:10.1097/00005344-200402000-00015
    摘要:Takishita E, Takahashi A, Harada N, Yamato M, Yoshizumi M, Nakaya Y. Effect of Sarpogrelate Hydrochloride, A 5-HT2 Blocker, on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty Rats (OLETF rats), A Type 2 Diabetic Rat Model. Journal of Cardiovascular Pharmacology. 2004 Feb;43(2):266–70. doi: 10.1097/00005344-200402000-00015.
    参考文献:10.1139/y03-108
    摘要:Saini HK, Sharma SK, Zahradka P, Kumamoto H, Takeda N, Dhalla NS. Attenuation of the serotonin-induced increase in intracellular calcium in rat aortic smooth muscle cells by sarpogrelate. Can J Physiol Pharmacol. 2003 Nov;81(11):1056–63. doi: 10.1139/y03-108.
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