CAS: 118712-89-3; Transfluthrin

该化合物是一种合成的除虫菊酯杀虫剂,以其有效控制各种害虫而闻名,其特点是它对哺乳动物毒性低,对昆虫的快速击倒效应,使之适合室内和室外使用;四氟氯菊酯通常用于家用杀虫剂,蚊虫驱虫剂和农业用途的配方;该物质无色可粉黄,有微弱的气味,在正常条件下相对稳定;其行动方式涉及破坏昆虫...

结构式图片

相似化合物

915288-13-0 28900-62-1 2940870-67-5

欧盟法规

ECHA物质C&L通报

上下游产品

(1R)-trans-3-(2,2-dichloro-1-ethenyl)-2,2-dimethylcyclopropanecarboxylic acid chloride (2,3,5,6-tetrafluorophenyl)methanol

合成工艺路线路线简述

  • 合成目标产物 Transfluthrin 主要起始原料 (1R-Trans)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarbonyl Chloride And 2,3,5,6-Tetrafluorobenzyl Alcohol
  • (文献来源)合成步骤主要原料 (1R-Trans)-3-(2,2-Dichlorovinyl)-2,2-Dimethylcyclopropanecarbonyl Chloride 和 2,3,5,6-Tetrafluorobenzyl Alcohol
Potassium;(1R,3S)-3-(2,2-Dichloroethenyl)-2,2-Dimethylcyclopropane-1-Carboxylate,2,3,5,6-四氟氯苄 以90%的收率获得
参考文献:Naumann,Klaus;Behrenz,Wolfgang
标题:Naumann,Klaus;Behrenz,Wolfgang

海关参考信息

专利信息


专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:US-2011230343-A1
优先权日:2008-10-24
标题 :Method for the Manufacture of Microparticles Comprising an Effect Substance
发明人:SCHROERS MICHAEL; DYLLICK-BRENZINGER RAINER; MERK MICHAEL; BARG HEIKO
权利人:BASF SE
摘要:A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M. In addition, the present invention relates to the use of microparticles M prepared according to the invention as component in colorants, cosmetics, drugs, biocides, plant protection agents, fertilizers, additives for food or animal fodder, or auxiliaries for polymers, paper, textiles, leather, detergents or cleaners. Finally, the invention also relates to a method for combating undesirable plant growth, to a method for combating undesirable insect or acarid infestation on plants and/or for combating phytopathogenic fungi, and to seeds treated with the agrochemical formulation.

专利号:US-10278395-B2
优先权日:2013-03-11
标 题 :Functionalized environmentally benign nanoparticles
发明人:VELEV ORLIN D; RICHTER ALEXANDER P
权利人:UNIV NORTH CAROLINA STATE
摘要:This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).

专利号:US-8937089-B2
优先权日:2004-07-01
标 题:Synergistic mixtures of anthranilamide invertebrate pest control agents
发明人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN
权利人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN; DU PONT
摘要:Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof n n n n n n n n n n n n andn na component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.n n n n n n Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.

专利号:US-11213031-B2
优先权日:2017-11-13
标 题:Tetrazolylpropyl derivatives and their use as fungicides
发明人:SUDAU ALEXANDER; HOFFMANN SEBASTIAN; DAHMEN PETER; WEBSTER ROBERT ALAN; MEISSNER RUTH; GOERTZ ANDREAS; MILLER RICARDA; COQUERON PIERRE-YVES; BERNIER DAVID; NICOLAS LIONEL; BRUNET STEPHANE; KENNEL PHILIPPE; TOQUIN VALERIE; GOURGUES MATHIEU; LOQUE DOMINIQUE; THOMAS VINCENT
权利人:BAYER AG; BAYER CROPSCIENCE AG
摘要:The present invention relates to tetrazolylpropyl derivatives of formula (I) n nwherein one of V 1 and V 2 represents CR 3 and the other one of V 1 and V 2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R 1 , R 2 , R 3 , R 4 , and R 5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.
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主要参考文献

[参考文献]: David Anuoluwapo Oyeniran, Et Al. Infertility: A Product Of Smoke Emanating From Transfluthrin Coated Insecticide Paper (Tcip).
[参考文献]: Nicholas J Martin, Et Al. The Impact Of Transfluthrin On The Spatial Repellency Of The Primary Malaria Mosquito Vectors In Vietnam: Anopheles Dirus And Anopheles Minimus. Malar J . 2020 Jan 6;19(1):9.
[参考文献]: Ulrich R Bernier, Et Al. The Use Of Microdispensers With Spatial Repellents For Personal Protection Against Mosquito Biting. J Med Entomol. 2016 Mar;53(2):470-2.

合成参考文献


参考文献:10.1016/j.jchromb.2012.11.025
摘要:Yoshida T. Analytical method for urinary metabolites of the fluorine-containing pyrethroids metofluthrin, profluthrin and transfluthrin by gas chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914():77–83. doi: 10.1016/j.jchromb.2012.11.025.
参考文献:10.1021/acs.joc.5b02022
摘要:Jia X, Wang J, Ding X, Yang J, Li N, Zhao N, Huang Z. Mg-Prompted Polyfluoroarene C-H Functionalization: Formal Synthesis of Transfluthrin, Fenfluthrin, and Tefluthrin. J Org Chem. 2015 Nov 06;80(21):10874–82. doi: 10.1021/acs.joc.5b02022.
参考文献:10.1371/journal.pone.0237353
摘要:Sukkanon C, Nararak J, Bangs MJ, Hii J, Chareonviriyaphap T. Behavioral responses to transfluthrin by Aedes aegypti, Anopheles minimus, Anopheles harrisoni, and Anopheles dirus (Diptera: Culicidae). PLoS ONE. 2020 Aug 12;15(8):e0237353. doi: 10.1371/journal.pone.0237353.
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