专利号:US-2009043069-A1 优先权日:2007-08-06 标 题 :Activated esters for synthesis of sulfonated telechelic polycarbonates 发明人:BRUNELLE DANIEL J; COLONNA MARTINO; FIORINI MAURIZIO; BERTI CORRADO; BINASSI ENRICO 权利人:GEN ELECTRIC 摘要:A process of making a sulfonated telechelic polycarbonate is described. A dihydroxy compound, a carbonate ester, and an activated ester of a sulfobenzoic acid salt are reacted together. The method results in a sulfonated telechelic polycarbonate which has a high percentage of sulfonated end groups, is soluble, and is transparent.
专利号:US-6943254-B2 优先权日:1997-03-07 标 题 :Synthesis of pyrazinyl pyridine-3-sulfonamide compounds 发明人:HOGAN PHILIP JOHN 权利人:ASTRAZENECA UK LTD 摘要:A process for the manufacture of: n n nwherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises:n (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: n n (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.
专利号:US-5939392-A 优先权日:1993-06-03 标 题 :Method of thrombin inhibition 发明人:ANTONSSON KARL THOMAS; BYLUND RUTH ELVY; GUSTAFSSON NILS DAVID; NILSSON NILS OLOV INGEMAR 权利人:ASTRA AB 摘要:The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.
专利号:US-7371852-B2 优先权日:2003-01-22 标 题 :Alkyl-linked nucleotide compositions 发明人:HARDEMAN KLASS P; HALL STEVEN E; WARE ROY W; HINKLEY LINDSAY A; JENKS MATTHEW G 权利人:SERENEX INC 摘要:Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.
专利号:CN-101365674-A 优先权日:2005-07-21 标题:Modulators of interleukin-1 and tumor necrosis factor alpha, synthesis of the modulators and methods of using the modulators
专利号:US-5723444-A 优先权日:1993-06-03 标 题:Starting materials in the synthesis of thrombin and kinogenase inhibitors