CAS: 997-68-2; Saccharopine
该化合物是一种非蛋白性生成的氨基酸衍生物,它是赖氨降解路径,特别是沙查罗平通道的中间体,在代谢研究和生化研究中发挥着关键作用,特别是在了解氨基酸催化物及相关疾病方面.L-Saccharopine因其纯度和稳定性很高而备受珍视,适合酶学实验,代谢特征分析以及体外研究.其明确界定的结构和一贯质量确保研究应用的可靠性能.它作为关键的代谢物,有助于解释代谢途径和超血清等遗传条件的潜在治疗目标.
- 英文名称Saccharopine
- 中文名称L-酵母氨酸
- IUPAC名称((S)-5-amino-5-carboxypentyl)-L-glutamic acid
- 其它别名Saccharopine; 2-[(5-Amino-5-Carboxy-Pentyl)Amino]Pentanedioic Acid; ε-N-(L-Glutar-2-yl)-L-Lysine, N6-(L-1,3-Dicarboxylpropyl)-L-Lysine; N-[(S)-5-Amino-5-Carboxypentyl]-L-Glutamic Acid; (S)-2-(((S)-5-Amino-5-Carboxypentyl)Amino)Pentanedioic Acid; N-(5-Amino-5-Carboxypentyl)-L-Glutamic Acid; N6-(L-1,3-Dicarboxylpropyl)-L-Lysine; ω-N-(L-Glutar-2-yl)-L-Lysine
- CAS编号997-68-2
- MFCD编号:MFCD00056743
- FDA UNII编号:WBQ73O8W32
- 分子式:C11H20N2O6分子量:276.29
- 产品CID: 2032664
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
- 熔点257-259°C (分解)
- 沸点537.2 °C at 760mmHg
- 闪点278.7 °C
- 密度1.333g/cm3
- PH:D23 +33.6° (c = 1 in 0.5N HCl)
- pKa:pK2 2.6; pK3 4.1; pK4 9.2; pK5 10.3(at 25°C)
- PSA:149.95
- LogP:0.5674
- 折射率1.537
- 溶解性Aqueous Acid (Slightly), Aqueous Base (Slightly)
- 敏感性1. 存在于烤烟烟叶中。
- 外观形态白色至类白色固体
- 储存条件−20°C
- 产品应用该化合物用作研究米托昆德里机能失调,赖氨代谢性新陈代谢紊乱和沙迦罗皮尼里亚病理机制,特别是在涉及AASS(Α-氨基阿迪帕特半甲丁二酰胺合成酶)突变的模型中.
MSDS等安全信息
上下游产品
CAS号56-87-1 L-赖氨酸 | CAS号64-15-3 2-oxoglutarate(2-)合成工艺路线路线简述
📜Nε-苄氧羰基-Nα-甲苯磺酰基-L-赖氨酸置于钯 盐酸,氢气体系中,用 丙酮 作为反应溶剂,化学反应生成 L-酵母氨酸
参考文献:Kjaer,A.; Olesen Larsen,P.,Acta Chemica Scandinavica (1947),1961,Vol. 15,P. 750-759
标题:Kjaer,A.; Olesen Larsen,P.,Acta Chemica Scandinavica (1947),1961,Vol. 15,P. 750-759
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2014028026-A9
优先权日:2012-08-17
标题:Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN
权利人:CELEXION LLC; BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
专利号:US-9102961-B2
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
权利人:CELEXION LLC
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries
专利号:US-11766412-B2
优先权日:2016-09-29
标 题:Methods of treating or alleviating adenylosuccinatelyase (ADSL) deficiency using spermidine or a pharmaceutically acceptable salt of spermidine
发明人：PAN WUGUANG; ZHU WEI
权利人:GENEHEAL BIOTECHNOLOGY CO LTD
摘要:Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
专利号:US-2012258504-A1
优先权日:2008-12-12
标题:Biological synthesis of difunctional alkanes from carbohydrate feedstocks
专利号:US-2013017593-A1
优先权日:2009-03-11
标题:Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Sato T, Ito Y, Nagasawa T. Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes. Biosci Biotechnol Biochem. 2016 Jul
18:1-8. [Epub ahead of print] doi: 10.1186/s40064-016-1809-1. eCollection 2016.
3: Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31;51(4):857-66. doi: 10.1021/bi201808. Epub 2012 Jan 23.
合成参考文献
参考文献:10.1038/s41467-021-24482-1
摘要:Wu P, Chen D, Ding W, Wu P, Hou H, Bai Y, Zhou Y, Li K, Xiang S, Liu P, Ju J, Guo E, Liu J, Yang B, Fan J, He L, Sun Z, Feng L, Wang J, Wu T, Wang H, Cheng J, Xing H, Meng Y, Li Y, Zhang Y, Luo H, Xie G, Lan X, Tao Y, Li J, Yuan H, Huang K, Sun W, Qian X, Li Z, Huang M, Ding P, Wang H, Qiu J, Wang F, Wang S, Zhu J, Ding X, Chai C, Liang L, Wang X, Luo L, Sun Y, Yang Y, Zhuang Z, Li T, Tian L, Zhang S, Zhu L, Chang A, Chen L, Wu Y, Ma X, Chen F, Ren Y, Xu X, Liu S, Wang J, Yang H, Wang L, Sun C, Ma D, Jin X, Chen G. The trans-omics landscape of COVID-19. Nature Communications. 2021 Jul 27;12(1):4543. doi: 10.1038/s41467-021-24482-1.
参考文献:10.1038/s41392-021-00549-9
摘要:Kong C, Yan X, Liu Y, Huang L, Zhu Y, He J, Gao R, Kalady MF, Goel A, Qin H, Ma Y. Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome. Signal Transduction and Targeted Therapy. 2021 Apr 23;6(1):154. doi: 10.1038/s41392-021-00549-9.
参考文献:10.1007/bf00714294
摘要:Kato T, Sano M. Effect of ammonium chloride on homocitrulline and homoarginine synthesis from lysine. J Inherit Metab Dis. 1993;16(5):906–7. doi: 10.1007/bf00714294.
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