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CAS号3430-26-0 2,5-二溴-4-甲基吡啶 | CAS号886364-94-9 5-溴-4-甲基吡啶-2-甲醛合成工艺路线路线简述
- 合成目标产物 5-Bromo-2-Iodo-4-Picoline 主要起始原料 2,5-Dibromo-4-Methylpyridine
- 3430-26-0 = 941294-57-1
反应条件:1.1 Reagents: Acetyl Chloride,Sodium Iodide Solvents: Acetonitrile; 0 °C -> 90 °C; 16 H,90 °C
标题:Preparation Of Arylamide Pyridine Oxides As Factor Xia Inhibitors For The Treatment And Prevention Of Thrombosis And Related Diseases
参考文献:United States]
3430-26-0 = 941294-57-1
反应条件:1.1 Reagents: Acetyl Chloride,Sodium Iodide Solvents: Acetonitrile; 3 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized,Rt
标题:Isoxazoline Derivatives As Insecticides And Their Preparation And Use
参考文献:World Intellectual Property Organization
📜2,5-二溴-4-甲基吡啶置于乙酰氯,Sodium Iodide,碳酸氢钠体系中,用 乙腈,水 作为反应溶剂,化学反应 3.0H,反应生成 5-溴-2-碘-4-甲基砒啶
参考文献:Insecticidal Compounds Based On Isoazoline Derivatives
标题:Insecticidal Compounds Based On Isoazoline Derivatives
摘要:本发明涉及式(I)的化合物:其中a1,A2,A3,A4,G1,L,Y1,Y2,Y3,Y4,R1,R2,R3和r4如权利要求1所定义;或其盐或n-氧化物.此外,本发明涉及制备式(I)化合物的中间体,包含它们的组合物以及使用它们来对抗和控制昆虫,螨虫,线虫和软体动物害虫的方法.
专利信息
专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
专利号:US-9187522-B2
优先权日:2011-12-12
标题 :GLP-1 receptor modulators
发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:RECEPTOS INC
摘要:The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
专利号:US-9598430-B2
优先权日:2013-06-11
标 题 :GLP-1 receptor modulators
发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:RECEPTOS INC; CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.