CAS: 92-43-3; 1-Phenyl-3-Pyrazolidinone

该化合物是主要用作摄影化学开发剂的有机化合物;它是白色的,白的,黄色的晶状固体,在水和有机溶剂中可以溶解;Phenidone以其能够生产优质的图像而闻名,具有细粒和鲜明对比,使它在黑白摄影中成为受欢迎的选择;化合物作为减少剂的作用,有助于在开发过程中将银卤化物转换为金属银;其化学结构有一个1-苯-3-酮框架,有助于其应用.此外,Phenidone因其稳定性和低毒性而与其他开发剂相比,如氢基酮,仍应受到重视,但与所有化学品一样,仍应谨慎处理,以避免潜在的健康风险.

结构式图片

欧盟法规

统一分类与标签REACH注册ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号59-88-1 盐酸苯肼 | CAS号140-88-5 丙烯酸乙酯 | CAS号100-63-0 苯肼 | CAS号3314-35-0 3-氨基-4,5-二氢-1-苯基吡唑 | CAS号41682-87-5 3-hydroxy-propi... | CAS号26955-79-3 3-(2-phenylhydr... | CAS号79-06-1 丙烯酰胺 | CAS号5883-17-0 N-乙基丙烯酰胺 | CAS号113410-22-3 4-(2-hydroxyeth... | CAS号2655-46-1 2-acetyl-1-phen... | CAS号65684-98-2 2-phenyl-5-(3,4... | CAS号58469-32-2 5-chloro-2-phen... | CAS号60588-53-6 2-苯基-4-苯基乙酰氨-3-... | CAS号61447-57-2 5-(4-fluorophen...

合成工艺路线路线简述

  • 合成目标产物 Phenidone 主要起始原料 Phenylhydrazine Hydrochloride And Acrylic Acid Methyl Ester
  • (文献来源)合成步骤主要原料 Phenylhydrazine Hydrochloride 和 Acrylic Acid Methyl Ester
3-氨基-4,5-二氢-1-苯基吡唑置于盐酸体系中,化学反应生成 菲尼酮
参考文献:Pietra,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1953,Vol. 11,P. 78,80
标题:Pietra,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1953,Vol. 11,P. 78,80

海关参考信息

专利信息


专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人:CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人:FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人:CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-4592867-A
优先权日:1984-10-19
标题:Synthesis method for reductant precursor
发明人:YU TERRY T; YEN MEI-RONG
权利人:ENERGY CONVERSION DEVICES INC
摘要:A synthesis method is provided for the synthesis of quinone compounds of the formula ##STR1## where n is 0-3, Y 1 is alkoxy, Y 2 is alkoxy, chloro, bromo or hydrogen and R' and R' each and independently are hydrogen, alkyl or phenyl. These compounds are useful as reductant precursors in tellurium imaging compositions.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人:BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-5527824-A
优先权日:1985-07-22
标题 :Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis
发明人:SCHERRER ROBERT A
权利人:RIKER LABORATORIES INC
摘要:Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.
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主要参考文献

[参考文献]: Moon C, Et Al. Phenidone, A Dual Inhibitor Of Cyclooxygenases And Lipoxygenases, Ameliorates Rat Paralysis In Experimental Autoimmune Encephalomyelitis By Suppressing Its Target Enzymes. Brain Res. 2005;1035(2):206-210.
[参考文献]: Petrakiev A, Et Al. Emission Spectral Analysis Using Photographic Plates Treated With A Phenidone Developer. Talanta. 1969;16(12):1583-1587.
[参考文献]: Stern N, Et Al. The Lipoxygenase Inhibitor Phenidone Is A Potent Hypotensive Agent In The Spontaneously Hypertensive Rat. Am J Hypertens. 1993;6(1):52-58.
[参考文献]: Ender Büyükgüzel, Et Al. The Influence Of Chronic Eicosanoid Biosynthesis Inhibition On Life History Of The Greater Waxmoth, Galleria Mellonella And Its Ectoparasitoid, Bracon Hebetor. J Insect Physiol. 2011 Apr;57(4):501-7.
[参考文献]: G P Rossi, Et Al. Endothelin-1 Stimulates Aldosterone Synthesis In Conn'S Adenomas Via Both A And B Receptors Coupled With The Protein Kinase C- And Cyclooxygenase-Dependent Signaling Pathways. J Investig Med. 2000 Sep;48(5):343-50.

合成参考文献


参考文献:10.1155/2011/385780
摘要:Burnett BP, Bitto A, Altavilla D, Squadrito F, Levy RM, Pillai L. Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant. Mediators Inflamm. 2011;2011():385780.
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