CAS: 87-17-2; 2-Hydroxy-N-Phenylbenzamide

该化合物是一种该化合物是一种强有力的细菌和真菌剂,对皮肤植物和其他微生物特别有效. 化合物的机理包括干扰微生物细胞膜,抑制对哺乳动物细胞没有重大毒性的生长. 盐氨基氨基磺在水中微弱地溶解,但在有机溶剂中表现出良好的溶解性,强化其配方的多功能性. 在中度条件下和广度活动,其稳定性在抗菌制剂和防腐剂等药物和农业应用中具有价值. 化合物的功效及其相对较低的环境持久性凸显了其在受控抗微生物用途中的效用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

phenyl N-phenylcarbamate sodium phenoxide 2-phenylcarbamoyloxy-benzoic acid methyl ester 2-(2-hydroxy-benzoyloxy)-benzoic acid anilide6,6'-dihydroxy-3,3'-methanediyl-di-benzoic acid dianilide 2-hydroxy-5-phenylazo-benzoic acid anilide Dibromsalan 2-(benzothiazol-2-yl)phenol

合成工艺路线路线简述

  • 90-02-8 = 87-17-2
    反应条件:1.1 Catalysts: (T-4)-[n-[2,6-Bis(1-Methylethyl)Phenyl]-1-[[[2,6-Bis(1-Methylethyl)Phenyl]Amino-... Solvents: Toluene; 2 H,Rt1.2 Reagents: Water; Rt
    标题:Cyclopentadienyl-Free Rare-Earth Metal Amides [{(Ch2Sime2){(2,6-Ipr2C6H3)N}2}Ln{n(Sime3)2}(Thf)] As Highly Efficient Versatile Catalysts For C-C And C-N Bond Formation
    作者:Wu,Yunjun; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2010 卷标:(2) 页码:326-332]

    90-02-8 = 87-17-2
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Ethyl Acetate; 6 H,Rt1.2 Reagents: Acetic Acid
    标题:Synthesis Of A Tripod-Type Ligand And Fluorescence Properties Of Its Rare Earth Complexes
    作者:Wu,Gen-Liang; Et Al
    参考文献:Ningxia Gongcheng Jishu 日期:2007 卷标:6(1) 页码:34-35]

    118-55-8 = 87-17-2
    反应条件:1.1 4 Min,Rt -> 171 °C
    标题:Synthesis Of Substituted Salicylanilides Under Microwave Irradiation
    作者:Veverkova,Eva; Et Al
    参考文献:Monatshefte Fuer Chemie 日期:2003 卷标:134(9) 页码:1215-1219]

    118-55-8 = 87-17-2 [标题:Reaction Conditions
    标题:Synthesis Of Some Substituted Salicylanilides Of Expected Biological Activity
    作者:Islam,A. M.; Et Al
    参考文献:Journal Fuer Praktische Chemie (Leipzig) 日期:1972 卷标:314(5-6) 页码:727-34]

    6833-21-2 = 87-17-2
    反应条件:1.1 Reagents: Piperazine Solvents: Dimethylacetamide1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Regioselective Dealkylation Of 2-Alkoxybenzoic Acid And Its Amide Derivatives With Aliphatic Amines
    作者:Nishioka,Hiroyasu; Et Al
    参考文献:Synthesis 日期:2000 卷标:(2) 页码:243-246]

    = 87-17-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; Overnight,Rt; Rt -> 0 °C1.2 Reagents: Ammonium Chloride Solvents: Water; Ph 7,0 °C
    标题:An Unusual N-Boc Deprotection Of Benzamides Under Basic Conditions
    作者:Yin,Biaolin; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2009 卷标:27(9) 页码:1645-1648]

    19263-30-0 = 87-17-2
    反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Toluene; 2 Min,Rt; 1 H,80 °C; Cooled1.2 Reagents: Sodium Bicarbonate Solvents: Ethyl Acetate,Water; Ph 7
    标题:Trifluoroacetic Acid-Mediated Denitrogenative Ortho-Hydroxylation Of 1,2,3-Benzotriazin-4(3H)-Ones: A Metal-Free Approach
    作者:Madasamy,Kanagaraj; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(13) 页码:8752-8756]

    858478-93-0 = 87-17-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane; 3 H,Rt
    标题:Convenient Synthesis Of Salicylanilide Sulfonates From 1,2,3-Benzotriazin-4(3H)-Ones And Organosulfonic Acids Via Denitrogenative Cross-Coupling
    作者:Korivi,Ramaraju; Et Al
    参考文献:Acs Omega 日期:2023 卷标:8(20) 页码:18306-18311]

    347370-91-6 = 87-17-2
    反应条件:1.1 Catalysts: Azobisisobutyronitrile,Tributylstannane Solvents: Toluene; 140 °C
    标题:An Unprecedented Synthesis Of N-Phenyl Amides Via Cleavage Of Benzotriazole Ring Under Free Radical Condition
    作者:Singh,Anoop S.; Et Al
    参考文献:Chemistryselect 日期:2017 卷标:2(1) 页码:224-229]

    69-72-7 = 87-17-2
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Xylene; 150 °C; 33 Min,150 °C
    标题:One-Pot Synthesis Of Salicylanilides By Direct Amide Bond Formation From Salicylic Acid Under Microwave Irradiation
    作者:Lu,Cheng-Rong; Et Al
    参考文献:Synthetic Communications 日期:2011 卷标:41(9) 页码:1257-1266]

    69-72-7 = 87-17-2
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene
    标题:Synthesis And Antimycobacterial Activity Of Salicylanilides Substituted In Position 5
    作者:Waisser,K.; Et Al
    参考文献:Chemical Papers 日期:2001 卷标:55(2) 页码:121-129]

    69-72-7 = 87-17-2
    反应条件:1.1 Catalysts: Magnesium Oxide; 15 Min,70 °C
    标题:Recyclable,Highly Efficient And Low Cost Nano-Mgo For Amide Synthesis Under Sfrc: A Convenient And Greener Nose' Approach
    作者:Das,Vijay Kumar; Et Al
    参考文献:Applied Catalysis 日期:2013 卷标:456 页码:118-125]

    118-55-8 = 87-17-2 [标题:Reaction Conditions
    标题:Pyrolysis Of O-Allyl Salicylic Amides And Esters,And Related Compounds: Formation Of Isoindolones And Phthalides
    作者:Black,Michael; Et Al
    参考文献:Journal Of The Chemical Society 日期:1994 卷标:(2) 页码:155-9]

    6833-21-2 = 87-17-2
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 30 Min,-78 °C; 1 H,0 °C1.2 Reagents: Methanol,Water; 20 Min,0 °C
    标题:Co And O2 Binding Studies Of New Model Complexes For Cco
    作者:Ladomenou,Kalliopi; Et Al
    参考文献:Polyhedron 日期:2013 卷标:54 页码:47-53]

    65-45-2 = 87-17-2
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Bis(Dibenzylideneacetone)Palladium,Bis(1,1-Dimethylethyl)[2′-(1-Methylethoxy)[1,1′-Binaphthalen]-2-Yl]Phosphine Solvents: Tert-Butanol; 20 H,100 °C; 100 °C -> Rt
    标题:Palladium-Catalyzed Amidation Of Aryl Halides Using 2-Dialkylphosphino-2'-Alkoxyl-1,1'-Binaphthyl As Ligands
    作者:Ma,Fangfang; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2012 卷标:77(12) 页码:5279-5285]

    65-45-2 = 87-17-2 [标题:Reaction Conditions
    标题:Arylamines
    作者:Scholz,U.; Et Al
    参考文献:Science Of Synthesis 日期:2007 卷标:31 页码:1565-1678]

    = 87-17-2
    反应条件:1.1 Solvents: Dichloromethane; 0 °C; 3 - 6 H,0 °C -> Rt1.2 Catalysts: 1,10-Phenanthroline,Cuprous Iodide Solvents: Water; 10 Min,Rt1.3 Reagents: Potassium Hydroxide; 10 H,100 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:A Highly Efficient Copper-Catalyzed Method For The Synthesis Of 2-Hydroxybenzamides In Water
    作者:Balkrishna,Shah Jaimin; Et Al
    参考文献:Synthesis 日期:2012 卷标:44(9) 页码:1417-1426]

    = 87-17-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; Overnight,Rt; Rt -> 0 °C1.2 Reagents: Ammonium Chloride Solvents: Water; Ph 7,0 °C
    标题:An Unusual N-Boc Deprotection Of Benzamides Under Basic Conditions
    作者:Yin,Biaolin; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2009 卷标:27(9) 页码:1645-1648]

    591-50-4 + 65-45-2 = 87-17-2
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Cuprous Iodide Solvents: Dimethyl Sulfoxide; 24 H,130 °C1.2 Solvents: Ethyl Acetate
    标题:Ligand-Free Ullmann-Type C-Heteroatom Couplings Under Practical Conditions
    作者:Gueell,Imma; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(15) 页码:3188-3195]

    591-50-4 + 65-45-2 = 87-17-2
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Copper Solvents: Butyronitrile; 14 H,120 °C
    标题:Activated Charcoal Supported Copper Nanoparticles: A Readily Available And Inexpensive Heterogeneous Catalyst For The N-Arylation Of Primary Amides And Lactams With Aryl Iodides
    作者:Zhao,Rong; Et Al
    参考文献:Tetrahedron 日期:2021 卷标:79]

    591-50-4 + 65-45-2 = 87-17-2
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Diethylenetriamine,Cuprous Iodide Solvents: Dimethyl Sulfoxide; 24 H,50 °C1.2 Reagents: Ethyl Acetate
    标题:Orthogonal Discrimination Among Functional Groups In Ullmann-Type C-O And C-N Couplings
    作者:Rovira,Mireia; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2016 卷标:81(17) 页码:7315-7325]

    321-14-2 = 87-17-2
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Toluene; 120 - 125 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2,120 - 125 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; Ph 8 - 9
    标题:Synthesis And Antibacterial Activity Of Some 1,3-Benzoxazin-2,4-Dione Derivatives
    作者:Truong,Phuong; Et Al
    参考文献:Tap Chi Duoc Hoc 日期:2006 卷标:46(1) 页码:14-17
N-羟基-2-苯氧基苯甲酰胺置于二叔丁基过氧化物,亚磷酸三乙酯体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 24.0H,以80%的收率获得产物水杨酰苯胺
参考文献:苯酚通过脱氧n中心自由基取代从苯酚中合成正式苯胺.
标题:苯酚通过脱氧n中心自由基取代从苯酚中合成正式苯胺.
摘要:酚类,木质素衍生的底物已成为偶联反应的理想生物可再生化学原料.据报道,使用未官能化的异羟肟酸作为n中心自由基源,可将苯酚衍生物自由基介导地转化为苯胺.在这项工作中证明了该亚磷酸三乙酯介导的o原子转移方法的适用性,该方法可耐受对天然存在的酚和木质素模型的一系列空间和电子需求,从而可获取相应的苯胺衍生物.
DOI:10.1002/chem.201904288

海关参考信息

专利信息


专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-8084495-B2
优先权日:2004-02-03
标题 :Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation for PPR-gamma receptors
发明人：HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN
权利人:HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN; HERBAL POWERS CORP
摘要:The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed as n ninhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B.n n The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).

专利号:US-8754259-B2
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
发明人：YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

专利号:US-4701527-A
优先权日:1983-12-05
标 题 :Synthesis of salicylamides with improved reaction kinetics and improved effective yields
发明人：KOERMER GERALD S; GUTIERREZ EDDIE N; PROROK MARYFRANCES
权利人:LEVER BROTHERS LTD
摘要:A method of synthesizing with improved reaction kinetics and improved effective yields salicylamide compounds of the formula: or wherein R1 is a substituent selected from the group consisting of -H, -COCnH2n+1 and -CnH2n+1 wherein n is an integer with a value of from 1 through to about 15, R2 is a substituent selected from the group consisting of -H, -CN, -NO2, -F, -Cl, -Br, -I, -CF3, -CBr3, -CCl3, -CI3 and R1 and R3 is an R2 substituted heterocyclic compound selected (e.g.) from the group consisting of furan, thiazole, benzothiazole and purine which comprises reacting a phenyl salicylate ester bearing an R1 substituent on the benzene ring of the salicylic acid portion thereof with an R2 substituted aniline or a heterocyclic amine NH2-R3 and with a Lowry-Bronsted acid catalyst, optionally in the presence of an inert solvent such as a halogenated or unhalogenated aromatic compound or a polyethylene glycol of average molecular weight 1000 to 6000 or mixtures thereof at a temperature of above about 150 DEG C. for about one half to about 4 hours. When the Lowry-Bronsted acid catalyst takes the form of the hydrochloride salt of the reactant aniline or heterocyclic amine the amount of the free reactant aniline or heterocyclic amine is reduced proportionately.

专利号:US-4659826-A
优先权日:1983-11-28
标 题:Synthesis of salicylamides with improved yield and purity
发明人：SCHWARZ JOSHUA
权利人:LEVER BROTHERS LTD
摘要:A method of synthesizing and recovering with high yield and purity salicylamide compounds of the formula: ##STR1## wherein R 1 is a substituent having the formula --COC n H 2n+1 wherein n is an integer with a value of from 1 through to about 15, R 2 is a substituent selected from the group consisting of --H, --NO 2 , --F, --Cl, --Br, --I, --CF 3 , --CBr 3 , --CCl 3 , --CI 3 and R 1 and R 3 is an R 2 substituted heterocyclic compound selected (e.g.) from the group consisting of furan, thiazole, benzothiazole and purine by: n (a) reacting a phenyl salicylate ester bearing an R 1 substituent on the benzene ring of the salicylic acid portion thereof with an R 2 substituted aniline or a heterocyclic amine NH 2 -R 3 , optionally in the presence of an inert solvent such as a halogenated or unhalogenated aromatic compound or a carbowax solvent, e.g., a polyethylene glycol of average molecular weight 1000 to 6000 or mixtures thereof at a temperature of above about 150° C. for about 2 to about 6 hours to form a reaction mixture; n (b) dissolving the reaction mixture in a solvent to form a dissolved reaction mixture; n (c) acidifying the dissolved reaction mixture with an aqueous solution of a Lowry-Bronsted acid to form an acidified dissolved reaction mixture; n (d) refluxing the acidified dissolved reaction mixture to produce a final reaction mixture; n (e) adding water to the final reaction mixture to precipitate the product salicylamide compound; and n (f) recovering the precipitated product salicylamide compound from the final reaction mixture.

专利号:US-7485741-B2
优先权日:2002-12-02
标 题:Method of producing nitrile compounds from ethylenically-unsaturated compounds
发明人：BOURGEOIS DAMIEN; GALLAND JEAN-CHRISTOPHE; DIDILLON BLAISE; MARION PHILIPPE
权利人:RHODIA POLYAMIDE INTERMEDIATES
摘要:The present invention relates to a process for hydrocyanating a hydrocarbon-based compound containing at least one ethylenic unsaturation by reaction in liquid medium with hydrogen cyanide in the presence of a catalyst comprising a metal element chosen from transition metals and an organophosphorus ligand, characterized in that the organophosphorus ligand is a monodentate organophosphorus compound. The present invention is in particular useful for the synthesis of adiponitrile from butadiene.

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1: Koller BH, Jania LA, Li H, Barker WT, Melander RJ, Melander C. Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination. Antimicrob Agents Chemother. 2024 Aug
28:e0067124. doi: 10.1128/aac.00671-24. Epub ahead of print.
192:114753. doi: 10.1016/j.foodres.2024.114753. Epub 2024 Jul 19. 12(7):1621. doi: 10.3390/biomedicines12071621.

合成参考文献


参考文献:10.2174/138955711797068382
摘要:Krátký M, Vinšová J. Antiviral activity of substituted salicylanilides--a review. Mini Rev Med Chem. 2011 Oct;11(11):956–67. doi: 10.2174/138955711797068382.
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