CAS: 865156-50-9; (4-Bromopyridin-2-yl)Methanamine

该化合物其结构特征为有机化合物,包括一个以溴原子和矿物质组组成的环状环状环状,以溴原子和矿物质组为替代品,该化合物具有丙烯基藻,有助于其芳香特性和进行各种化学反应的潜力;溴原子的存在增强了其反应性,使其成为有机合成的有益中间体,特别是在制药和农用化学的开发方面;该地雷组提供了基本性和核分子,允许其进一步功能化;该化合物一般在室温下是固体,由于矿物质组的存在,在极地溶剂中可能表现出中等溶解性;其特性,如熔点,沸点和溶性,可根据样品的具体条件和纯度而有所不同;

结构式图片

相似化合物

1779128-18-5 1060813-12-8 62150-46-3

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号62150-45-2 4-溴吡啶-2-甲腈 | CAS号22282-99-1 2-甲基-4-溴吡啶 | CAS号100367-74-6 4-溴-2-甲基吡啶-N-氧化物 | CAS号131747-45-0 2-羟甲基-4-溴吡啶 | CAS号131747-63-2 4-溴吡啶-2-甲醛 | CAS号865156-48-5 7-溴咪唑并[1,5-a]吡啶

合成工艺路线路线简述

  • 131747-45-0 = 865156-50-9
    反应条件:1.1 Reagents: Phthalimide,Triphenylphosphine Solvents: Tetrahydrofuran; 10 Min,0 °C1.2 Reagents: Diisopropyl Azodicarboxylate; 0 °C; 0 °C -> Rt; Overnight,Rt1.3 Reagents: Hydrazine Solvents: Ethanol; 2 H,Rt -> Reflux1.4 Reagents: Potassium Hydroxide Solvents: Ethyl Acetate; 20 Min,Rt
    标题:Dual-Catalytic Enantioselective Allylation Of N-(Heteroaromatic-Methyl)Imine Derivatives
    作者:Kim,Sangyun; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(12) 页码:7821-7829]

    131747-45-0 = 865156-50-9
    反应条件:1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran; 10 Min,0 °C1.2 Reagents: Diisopropyl Azodicarboxylate; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Hydrazine Solvents: Ethanol; 2 H,Rt -> Reflux2.2 Reagents: Potassium Hydroxide Solvents: Water; 20 Min,Rt
    标题:Dual-Catalytic Enantioselective Allylation Of N-(Heteroaromatic-Methyl)Imine Derivatives
    作者:Kim,Sangyun; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(12) 页码:7821-7829]

    1834611-93-6 = 865156-50-9
    反应条件:1.1 Reagents: Hydrazine Solvents: Ethanol; 2 H,Rt -> Reflux1.2 Reagents: Potassium Hydroxide Solvents: Water; 20 Min,Rt
    标题:Dual-Catalytic Enantioselective Allylation Of N-(Heteroaromatic-Methyl)Imine Derivatives
    作者:Kim,Sangyun; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(12) 页码:7821-7829
📜在 三氟乙酸,锌体系中,化学反应生成 4-溴吡啶-2-甲胺
参考文献:人类碳酸酐酶ii作为宿主蛋白,用于创建人造金属酶:亚胺的不对称转移氢化†
标题:人类碳酸酐酶ii作为宿主蛋白,用于创建人造金属酶:亚胺的不对称转移氢化†
摘要:在人碳酸酐酶ii的存在下,带有芳基-磺酰胺的ircp *钢琴凳配合物催化亚胺的不对称转移氢化.关键辅因子-蛋白质相互作用揭示由[(η的x射线结构5-Cp *)ir(微微4)cl] 9 ⊂wt Hca Ii是基因最优化以改善人工金属酶的催化性能(68%ee的,K Cat / K M 6.11x10-3 Min-1 Mm-1).
DOI:10.1039/c3Sc51065D

海关参考信息

专利信息


专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer

专利号:EP-3083583-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof

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