CAS: 851755-56-1; (R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-yl)Vinyl)Phenyl)-3-(2-(Methoxycarbonyl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid
- 英文名称(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-yl)Vinyl)Phenyl)-3-(2-(Methoxycarbonyl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid
- 中文名称孟鲁斯特杂质H
- IUPAC名称(R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(methoxycarbonyl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid
- 其它别名(R)-2-[1-[[[1-[3-[(E)-2-(7-Ch; 2-[(3R)-3-[[[1-(CarboxyMethyl)cyclopropyl]Methyl]thio]-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]benzoic Acid 1-Methyl Ester; 2'-Des(1-hydroxy-1-Methylethyl)-2'-Methycarboxy Montelukast; Montelukast IMpurity H
- CAS编号851755-56-1
- MFCD编号:MFCD23380775
- FDA UNII编号:KUW20633YM
- 分子式:C34H32ClNO4S分子量:586.15
- 产品CID: 2500276
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
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CAS号158966-92-8 孟鲁司特 | CAS号151767-02-1 孟鲁司特钠 | CAS号937275-23-5 孟鲁司特甲酮合成工艺路线路线简述
- 152922-73-1 + 1351973-20-0 = 851755-56-1
反应条件:1.1 Reagents: Methanesulfonyl Chloride,Diisopropylethylamine Solvents: Dichloromethane; 1 H,0 °C; 2 H,0 °C1.2 Reagents: Sodium Methoxide Solvents: Methanol,Dimethylformamide; 0.5 H,-5 °C; 1 H,-5 °C1.3 Solvents: Dimethylformamide; 1 H,-5 °C; 18 H,0 - 5 °C
标题:Identification,Synthesis And Characterization Of Impurities Of Montelukast Sodium
作者:Kumar,I. V. Sunil; Anjaneyulu,G. S. R.; Bindu,V. Hima
参考文献:Asian Journal Of Chemistry 日期:2011 卷标:23(10) 页码:4536-4546
📜(E)-2-[3-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-氧代丙基]苯甲酸甲酯置于sodium Methylate,N,N-二异丙基乙胺,(-)-Diisopinocamphenylborane Chloride体系中,用 甲醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 23.5H,反应生成 孟鲁斯特杂质h
参考文献:Sunil Kumar; Anjaneyulu; Hima Bindu,Asian Journal Of Chemistry,2011,Vol. 23,# 10,P. 4536-4546
标题:Sunil Kumar; Anjaneyulu; Hima Bindu,Asian Journal Of Chemistry,2011,Vol. 23,# 10,P. 4536-4546
海关参考信息
- 2901210000-乙烯
2902500000-苯乙烯
2902600000-乙苯
2903919090-氯苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7786138-B2
优先权日:2005-11-18
标题 :Process for making montelukast and intermediates therefor
发明人：BENOVSKY PETR; THIJS LAMBERTUS; OVEREEM ARJANNE; CASTULIK JAKUB; ZHU JIE; BARTOS PETR; SKOUMAL RADOMIR
权利人:SYNTHON BV
摘要:A compound of the following formula n nwherein R′ is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.
