CAS: 70872-29-6; (S)-7-Hydroxy-2-(4-Hydroxyphenyl)-5-Methoxy-8-(3-Methylbut-2-En-1-yl)Chroman-4-One

上下游产品

xanthoarnol xanthohumol desmethylxanthohumol 2-(4-acetoxyphenyl)-5-hydroxy-4-ox°Chroman-7-yl acetate2'',3''-dihydroisoxanthohumol

📜黄腐酚置于sodium Hydroxide体系中,用 水 作为反应溶剂,以90 %的收率获得产物异黄腐醇
参考文献:异黄腐醇胺类共聚物及其制备方法和抗菌应用
标题:异黄腐醇胺类共聚物及其制备方法和抗菌应用
摘要:本发明公开了一系列异黄腐醇胺类共聚物及其制备方法和抗菌应用.该系列化合物以黄腐醇为母体,将黄腐醇转化成为异黄腐醇,之后将异黄腐醇作为亲脂性部分,通过不同长度的烷基连接物与各种不同的脂肪胺和杂环胺相连,合成了一系异黄腐醇胺型共聚物,在此基础上可以继续进行结构优化,在其氮原子部位引入甲基形成氮正离子.本发明制得的异黄腐醇胺类共聚物对金黄色葡萄球菌atcc 29213和各种耐甲氧西林金黄色葡萄球菌(Mrsa)具有较好的抑菌效果,并且具有水溶性好,生物毒性低,产率较高等优点,有望进一步发展为临床上的半合成抗菌药物.

专利信息

专利号:US-2008221377-A1
优先权日:2006-06-16
标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:US-2009099061-A1
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
发明人：FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

专利号:US-2007015735-A1
优先权日:2005-03-23
标 题 :Water-dispersible carotenoids, including analogs and derivatives
发明人：LOCKWOOD SAMUEL F; NADOLSKI GEOFF
权利人:LOCKWOOD SAMUEL F; NADOLSKI GEOFF
摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The analog, derivative, or intermediate may be administered such that a subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:WO-2007090095-A2
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics

专利号:ES-2955412-T3
优先权日:2021-05-07
标题:A method of xanthohumol synthesis