CAS: 68206-94-0; Ethyl 2-((8-Chloro-3-(2-(Diethylamino)Ethyl)-4-Methyl-2-Oxo-2H-Chromen-7-yl)Oxy)Acetate
该化合物是一种化学化合物,属于染色体类别,其特点是有引信苯和皮兰环结构,因其生物活动,这种物质因其在各个领域的潜在应用而闻名,包括医药和农用化学,其生物活动;克隆人展示的特性可能包括抗氧化剂和防炎效应,使其对药用化学感兴趣;其分子结构有助于其再活动以及与生物系统的互动;如同许多化学物质一样,安全和处理预防措施必不可少,因为如果管理不当,克隆人可能带来风险;正在对其具体应用,行动机制以及环境影响进行研究,强调了解其有益用途和潜在危害的重要性;总的来说,克隆人是一种化合物,对科学研究和工业具有不同影响.
- 英文名称Ethyl 2-((8-Chloro-3-(2-(Diethylamino)Ethyl)-4-Methyl-2-Oxo-2H-Chromen-7-yl)Oxy)Acetate
- 中文名称氯克罗孟
- IUPAC名称ethyl 2-((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetate
- 其它别名Ethyl 2-[8-Chloro-3-(2-Diethylaminoethyl)-4-Methyl-2-Oxochromen-7-Yl]Oxyacetate; Cromocap; Proendotel; 8-Chlorocarbochromen; [[8-Chloro-3-[2-(Diethylamino)Ethyl]-4-Methyl-2-Oxo-2H-1-Benzopy- Ran-7-Yl]Oxy]Acetic Acid Ethyl Ester; Aceticacid,((8-Chloro-3-(2-(Diethylamino)Ethyl)-4-Methyl-2-Oxo-2H-1-Benzopyra; Ad6(Pharmaceutical); Cloricromen
- CAS编号68206-94-0
- MFCD编号:MFCD00868253
- EINECS号:636-182-9
- FDA UNII编号:B9454PE93C
- 分子式:C20H26ClNO5分子量:395.88
- 产品CID: 1670868
- 同类组份化合物CAS68206-94-0 (free base)74697-28-2 (HCl)
- 产品分类原料药 → 血液系统用药 → 抗凝血药及抗血小板药
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
📜Mono-Ethoxycarbonyl Methyl-2-Chloro-Resorcinol置于对甲苯磺酸体系中,用 Ppa 作为反应溶剂,化学反应生成 氯克罗孟
参考文献:Monohalogenated Derivatives Of 7-Hydroxy-Coumarin,Pharmaceutical
标题:Monohalogenated Derivatives Of 7-Hydroxy-Coumarin,Pharmaceutical
摘要:描述了一种选择性过程,用于生产7-羟基香豆素的单卤代衍生物,其中卤代取代基位于所需位置,最终产品不含其他单卤代异构体.得到的产品和含有这些产品的药物组合物,特别是其中卤代取代基位于8位的那些,具有有价值的特异性冠脉扩血管活性.
海关参考信息
- 2903919090-氯苯
2905310000-1,2-乙二醇
2909110000-乙醚
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📌 第三方产品分析报告
主要参考文献
1: Gao L, Wang F, Chen Y, Li F, Han B, Liu D. The antithrombotic activity of natural and synthetic coumarins. Fitoterapia. 2021 Oct;154:104947. doi: 10.1016/j.fitote.2021.104947. Epub 2021 Aug 2. 50(8):3846-52. doi: 10.1167/iovs.08-3328. Epub 2009 Mar 11. 23(3):257-63. doi: 10.1089/jop.2006.141. 58(7):1001-5. doi: 10.1211/jpp.58.7.0017. 7(1):E27. doi: 10.1208/pt070127.
6: Muià C, Mazzon E, Zito D, Maiere D, Britti D, Crisafulli C, Oteri G, Cordasco G, Cuzzocrea S. Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2006 Apr;373(1):51-9. doi: 10.1007/s00210-006-0048-3. Epub 2006 Mar 28. 7(1):E192-E198. doi: 10.1208/pt070127. Epub 2017 Mar 8. 78(8):785-94. doi: 10.1016/j.lfs.2005.05.077. Epub 2005 Aug 26. 370(2):140-5. doi: 10.1007/s00210-004-0956-z. Epub 2004 Jul 30. 56(7):841-6. doi: 10.1211/0022357023835. 278(1):133-41. doi: 10.1016/j.ijpharm.2004.03.002. 74(22):2749-56. doi: 10.1016/j.lfs.2003.10.016. 10(4):245-50. doi: 10.1080/drd_10_4_245. 44(3):1178-84. doi: 10.1167/iovs.02-0559. 767(1):153-8. doi: 10.1016/s1570-0232(01)00567-0. 56(4):403-7. 418(3):231-7. doi: 10.1016/s0014-2999(01)00910-4. 131(7):1399-407. doi: 10.1038/sj.bjp.0703695.
19: Gresele P, Migliacci R, Di Sante G, Nenci GG; CRAMPS Investigator Group. Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized Arteriopathy Multicenter Prospective Study. Vasc Med. 2000;5(2):83-9. doi: 10.1177/1358836X0000500204. 31(4):495-502.
合成参考文献
参考文献:10.1016/j.ijpharm.2004.03.002|10.1016/s0378-5173(04)00171-1
摘要:Leo E, Brina B, Forni F, Vandelli MA. In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form. International Journal of Pharmaceutics. 2004 Jun;278(1):133–41. doi: 10.1016/j.ijpharm.2004.03.002.
参考文献:10.1016/0378-4347(92)80185-s
摘要:Mariot R, Zangirolami L, Bellato P, Chen S, Pieraccini G, Moneti G. Determination of the coumarin derivative cloricromene acid in rabbit plasma and platelets. Journal of Chromatography B: Biomedical Sciences and Applications. 1992 Apr;576(1):143–8. doi: 10.1016/0378-4347(92)80185-s.
参考文献:10.1016/1043-6618(92)90541-i
摘要:Emanuela S, Maurizio P, Marco P, Rocco C. Peripheral ischemia in rabbit hindlimb: effect of cloricromene. Pharmacol Res. 1992 Feb;25 Suppl 1():63–4. doi: 10.1016/1043-6618(92)90541-i.
参考文献:10.1007/bf00504872
摘要:Prosdocimi M, Zatta A, Gorio A, Zanetti A, Dejana E. Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):305–10. doi: 10.1007/bf00504872.
参考文献:10.1016/0014-2999(93)90368-r
摘要:Zingarelli B, Carnuccio R, Di Rosa M. Cloricromene inhibits the induction of nitric oxide synthase. Eur J Pharmacol. 1993 Oct 19;243(2):107–11. doi: 10.1016/0014-2999(93)90368-r.
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