CAS: 6730-83-2; (4R,4As,6As,9S,11Ar,11Bs)-4,11B-Dimethyl-8-Methylenetetradecahydro-6A,9-Methanocyclohepta[a]Naphthalene-4-Carboxylic Acid

该化合物是一种自然产生的三乙基酸,以其多种生物活动著称,它具有很强的抗炎和抗氧化特性,成为制药和食堂应用的宝贵化合物,其结构完整性和纯度确保药物发展和皮肤护理产品得到有效利用.

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上下游产品

3-hydroxy-3-methylpentanoic acid D,L-mevalonic acid kaurene (-)-kaur-16-en-19-ol 16β-hydro-ent-kauran-17,19-dioic acid kaurenoic acid methyl ester 15α-hydroxy-ent-kaur-16-en-19-oic acid

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    专利信息


    专利号:US-10533205-B1
    优先权日:2013-10-09
    标 题:Kaurenoic acid glycoside precursors and methods of synthesis
    发明人：ZIPP BRANDON
    权利人:VITALITY BIOPHARMA INC
    摘要:Ent-kaurenoic acid glycoside precursor compositions and synthesis methods are provided. The KA-19-monoside, KA-19-bioside and KA-19-trioside precursors can be used as starting materials for a variety of kaurenoic acid based reactions. The precursors provide alternative synthesis pathways for steviol glycosides to the natural pathway based on Steviol biosynthesis. The alternative synthesis pathways using the precursors also circumvent the rate limiting step of the natural Steviol biosynthesis pathway. The precursors can be used individually or in combination to produce a mixture or individual steviol glycosides such as Rebaudioside A, Rebaudioside D or Rebaudioside M. Control over the precursor quantities and composition allows control over the composition of the resulting steviol glycosides that are finally produced.

    专利号:US-7119223-B2
    优先权日:1999-05-14
    标题:Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators

    专利号:US-2006252832-A1
    优先权日:1999-05-14
    标题 :Novel interleukin-1 and tumor necrosis factor-alpha modulators, synthesis of said modulators and their enantiomers and methods of using said modulators

    专利号:ES-2295031-T3
    优先权日:1999-05-14
    标 题:NEW MODULATORS OF INTERLEUCINE-1 AND TUMOR NECROSIS FACTOR, SYNTHESIS OF SUCH MODULATORS AND METHODS OF USE OF SUCH MODULATORS.

    专利号:ES-2337264-T3
    优先权日:1999-05-14
    标题:MODULATORS OF INTERLEUCINE-1 AND THE FACTOR-ALPHA OF TUMOR NECROSIS, SYNTHESIS OF SUCH MODULATORS AND METHODS OF USE OF SUCH MODULATORS.

    专利号:JP-2009505954-A
    优先权日:2005-07-21
    标题 :Interleukin-1 and tumor necrosis factor-a modifier, synthesis of such modifiers and methods of using such modifiers

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    主要参考文献


    1: Miyazaki S, Nakajima M, Kawaide H. Hormonal diterpenoids derived from ent-kaurenoic acid are involved in the blue-light avoidance response of Physcomitrella patens. Plant Signal Behav. 2015;10(2):e989046. doi: 10.4161/15592324.2014.989046.
    2: Silva JJ, Pompeu DG, Ximenes NC, Duarte AS, Gramosa NV, Carvalho Kde M, Brito GA, Guimarães SB. Effects of Kaurenoic Acid and Arginine on Random Skin Flap Oxidative Stress, Inflammation, and Cytokines in Rats. Aesthetic Plast Surg. 2015 Dec;39(6):971-7. doi: 10.1007/s00266-015-0559-8. Epub 2015 Sep 25. doi: 10.1155/2015/392918. Epub 2015 May 13.
    4: Miyazaki S, Kimura H, Natsume M, Asami T, Hayashi KI, Kawaide H, Nakajima M. Analysis of ent-kaurenoic acid by ultra-performance liquid chromatography-tandem mass spectrometry. Biochem Biophys Rep. 2015 May 30;2:103-107. doi: 10.1016/j.bbrep.2015.05.010. eCollection 2015 Jul.

    合成参考文献


    参考文献:10.1186/1471-2164-9-275
    摘要:Wechter WP, Levi A, Harris KR, Davis AR, Fei Z, Katzir N, Giovannoni JJ, Salman-Minkov A, Hernandez A, Thimmapuram J, Tadmor Y, Portnoy V, Trebitsh T. Gene expression in developing watermelon fruit. BMC Genomics. 2008 Jun 05;9():275.
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