CAS: 6228-47-3; Triphenyl(Propyl)Phosphonium Bromide

上下游产品

CAS号106-94-5 溴代丙烷 | CAS号603-35-0 三苯基膦 | CAS号71-23-8 正丙醇 | CAS号622-85-5 丙氧基苯 | CAS号6399-81-1 三苯基膦氢溴酸盐 | CAS号10411-39-9 CIS-15-°CTADECE... | CAS号488-10-8 顺茉莉酮 | CAS号24448-83-7 methyl 2-(triph... | CAS号64275-74-7 (E)-5-°Ctene-1-ol | CAS号64275-73-6 顺式-5-辛烯-1-醇 | CAS号33580-05-1 fucoserratene | CAS号33580-04-0 trans-trans-°Ct... | CAS号34010-23-6 methyl tetradec... | CAS号31502-19-9 (Z)-6-nonen-1-ol

溴丙烷,三苯基膦 以 甲苯 作为反应溶剂,化学反应 12.0H,以47.7%的收率获得产物三苯基丙基溴化
参考文献:β-Amyrin的生物合成:氧化角鲨烯底物中23位立体异构体的混杂,以及30位甲基与结合位点之间的疏水相互作用的意义
标题:β-Amyrin的生物合成:氧化角鲨烯底物中23位立体异构体的混杂,以及30位甲基与结合位点之间的疏水相互作用的意义
摘要:研究如何在(3的23位置上的空间相互作用小号)-2,3-环氧角鲨烯1只影响在polycyclization级联β香树脂醇的生物合成,与乙基(取代的底物类似物10,11),氢原子(12,13),或将23位的丙基残基(14)与β-淀粉酶合成酶孵育.笨重乙基被接受作为底物,从而导致在形成β香树脂醇骨架(的42,43而不多个环化反应的截断).类似物13,在23 E和23处具有氢原子和乙基z位置也分别转化为β-锚蛋白骨架45.但是,在23 Z位置(12)缺少乙基的类似物几乎未发生转化,强烈表明烷基必须存在于z位置.在z位置(14)具有丙基取代基的类似物的环化作用较差.在23 E位置具有cH2Oh的类似物15由于捕获了最终的齐墩果酸阳离子而以高收率提供了新的化合物47.相反,带23 Z-Ch的162个oh,得到新的化合物48-50在低的产率,这导致从中间dammarenyl和baccharenyl阳离子.因此,23
DOI:10.1021/acs.Joc.6B01313

专利信息

专利号:WO-2024105421-A1
优先权日:2022-11-17
标题 :SYNTHESIS OF α,β-UNSATURATED CARBONYLS FROM ALKENES VIA SULFONIUM INTERMEDIATES AND THEIR APPLICATION IN THE SYNTHESIS OF CONJUGATED DIENE PHEROMONES, KAIROMONES, AND RELATED COMPOUNDS
发明人：ANGYAL PÉTER; KOTSCHY ANDRÃ?S MIKLÓS; DUDÃ?S Ã?DÃ?M; SOÓS Tibor; VARGA SZILÃ?RD
权利人:TERMESZETTUDOMANYI KUTATOKOEZPONT; EOETVOES LORAND TUDOMANYEGYETEM
摘要:α,β-Unsaturated aldehydes are useful products as such in agrochemistry, but also potential intermediates for the preparation of important insect pheromones and kairomones. Until now, primarily the thermodynamically more stable (E)-α,β-unsaturated aldehydes have been identified as useful intermediates in the production of conjugated diene pheromone compounds, however, their practical and cost-effective synthesis on an industrial scale remains challenging. The problem to be solved by the present invention is to provide a method for selective oxidation of alkenes to α,β-unsaturated carbonyls which can be further transformed into pheromones and kairomones preferably without isolation and significant loss of the existing stereochemical purity.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-7968736-B2
优先权日:2002-09-06
标 题:Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
发明人：CURRAN DENNIS P; SHIN YOUSEUNG; CHOY NAKYEN; DAY BILLY W; BALACHANDRAN RAGHAVAN; MADIRAJU CHARITHA; TURNER TIFFANY
权利人:UNIV PITTSBURGH & MDASH OF THE COMMONWELTH SYSTEMS OF HIGHER EDUCATION
摘要:A compound of the following structure: n n n n n n n n n n wherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; n R 2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; n R a , R b and R c are independently an alkyl group or an aryl group; n R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; n R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; n R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CHâ•?CH—, —CHâ•?C(CH 3 )—, or —C≡C—; n R 4 n n n n n n n n n n n n  wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R k1 , R k2 , R k3 , R k4 and R k5 are independently H, CH 3 , or OR 2a , and R s1 , R s2 , R s3 , and R s4 are independently H or CH 3 , wherein R 2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; and n R 5 is H or OR 2b , wherein R 2b is H, an alkyl group, an aryl group, an aryl group,a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e .

专利号:US-2023303474-A1
优先权日:2020-07-30
标 题 :Total syntheses of specialized pro-resolving mediators (spms), structural isomers and structural analogs
发明人：MARETTE ANDRÉ; MALTAIS RENÉ; POIRIER DONALD; SANCÉAU JEAN-YVES
权利人:UNIV LAVAL
摘要:A method for the synthesis of specialized pro-resolving mediators, structural isomers thereof and analogs thereof is disclosed herein. The method comprises reacting a compound of the formula (I): n n n n n n n n n n n n wherein R 1 is alkyl (C≤12) , cycloalkyl (C≤12) , alkenyl (C≤12) , alkylidene (C≤12) , alkynyl (C≤12) , aryl, aralkyl, heteroaryl or heteroaralkyl; and X 1 , X 2 and X 3 are each independently hydroxy or OP, wherein P is a hydroxy protecting or hydroxy activating group; with a reducing agent under conditions sufficient to produce a compound of the formula (II): n n n n n n n n n n n n n n n n wherein: R 1 , X 1 , X 2 and X 3 are as defined above. n n n n n Novel protectins, more specifically novel structural isomers and analogs of PD1 and PDX are also disclosed.

专利号:US-12049443-B2
优先权日:2018-12-10
标题 :Synthesis of conjugated diene pheromones and related compounds
发明人：WAMPLER KEITH M; LEE CHOON WOO; ROZZELL DAVID
权利人:PROVIVI INC
摘要:Methods for preparing conjugated dienes are described. An α,β-unsaturated E olefin intermediate may be prepared via cross-metathesis using a catalyst comprising a transition metal (e.g., ruthenium), a first carbene ligand (e.g., a substituted indenylidene) and an N-heterocyclic carbene ligand (e.g., an imidazolidinylidene). The catalyst further includes a phenylphosphine ligand, a tri(isopropoxy)phosphine ligand, a dimethylsulfoxide ligand, an acetonitrile ligand, or a pyridine ligand. Following the cross metathesis-step, the α,β-unsaturated aldehyde intermediate may be converted to the conjugated diene product via reaction with a phosphonium ylide. Products obtained via the methods of the disclosure include (7E,9Z)-dodeca-7,9-dien-1-yl acetate, a pheromone produced by Lobesia botrana (European grapevine moth), and other insect pheromones.

专利号:WO-0144185-A1
优先权日:1999-12-16
标题 :Carbon monoxide-based synthesis of spla2 inhibitors
发明人：SAWYER JASON SCOTT
权利人:LILLY CO ELI; SAWYER JASON SCOTT
摘要:A method of making a compound, comprises reacting a compound represented by formula (I), with CO and a catalyst, to form the compound of formula (II); where formula (I) is and, formula (II) is and where R2 is selected from the group consisting of R20 -OR20, -SR20, -NR20R20'and -C(O)R20; R3, R4, R5, R6 and R7 are each individually selected from the group consisting of H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R and -S(O)2R; provided that at least one of R4 and R5 is not H; each R and R20 is individually selected from the group consisting of alkyl, alkenyl, alkynyl, aryl and heterocyclic radical; and each R' and R20' is individually selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl and heterocyclic radical. The method provides an alternative route to indole-3-glyoxylamide compounds.