CAS: 5631-68-5; 3-(2,4-Dihydroxyphenyl)Propionic Acid

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CAS号542-76-7 β-氯丙腈 | CAS号108-46-3 间苯二酚 | CAS号2141-62-0 3-乙氧基丙腈 | CAS号107-13-1 丙烯腈 | CAS号93-35-6 伞形花内酯; 7-羟基香豆素 | CAS号5631-67-4 7-羟基苯并二氢吡喃-2-酮 | CAS号412017-21-1 7-acetoxy-chrom... | CAS号7732-18-5 水 | CAS号7647-01-0 盐酸 | CAS号60-29-7 乙醚 | CAS号108-46-3 间苯二酚 | CAS号17422-90-1 3-(2,4-二羟基苯基)丙酸甲酯 | CAS号22174-29-4 3-(2,4-二甲氧基苯基)丙酸 | CAS号5631-67-4 7-羟基苯并二氢吡喃-2-酮

合成工艺路线路线简述

    7-羟基香豆素置于sodium Hydroxide,Palladium On Activated Charcoal体系中,化学反应生成 3-(2,4-二羟基苯)丙酸
    参考文献:Bridge Et Al.,Journal Of The Chemical Society,1937,P. 1530,1534
    标题:Bridge Et Al.,Journal Of The Chemical Society,1937,P. 1530,1534

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    专利信息


    专利号:US-11746364-B2
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
    发明人:PLUSKAL TOMÃ?S; Weng jing-ke
    权利人:WHITEHEAD INST BIOMEDICAL RES
    摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

    专利号:US-6229055-B1
    优先权日:1996-04-12
    标题 :Synthesis of fluorinated xanthene derivatives
    发明人:KLAUBERT DIETER H; GEE KYLE R
    权利人:MOLECULAR PROBES INC
    摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

    专利号:WO-2025181827-A2
    优先权日:2024-02-26
    标 题:Process development for substituted resorcinol production from cyclohexane-1,3-diones
    发明人:DAS PRALAY; YAMINI; MEHRA PUSHKAR; KUMAR ASHISH; BAINS ROHIT; KUMAR AJAY; RAM SHANKAR; SHARMA DHARMINDER; CHAUHAN ARVIND SINGH
    权利人:COUNCIL SCIENT IND RES
    摘要:The invention provides a scalable and low cost process for synthesis of different high value 4-alkyl resorcinols such as 3-(2,4-dihydroxyphenyl)propanoic acid, 3-(2,4- dihydroxy-5-methylphenyl)-2-methylpropanoic acid, 4-methyl resorcinol, 4-isopropyl resorcinol and 4-hexyl resorcinol from their corresponding cyclohexane-1,3-diones. The present invention also provides a process for preparing cyclohexane-1,3-diones which is the starting materials for the synthesis of resorcinols.

    专利号:US-11739354-B2
    优先权日:2018-01-17
    标 题 :Enzymatic synthesis of kavalactones and flavokavains

    专利号:US-2022002768-A1
    优先权日:2018-01-17
    标题:Enzymatic synthesis of kavalactones and flavokavains
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    主要参考文献

    [参考文献]: Shimizu K, Et Al. Novel Vitamin E Derivative With 4-Substituted Resorcinol Moiety Has Both Antioxidant And Tyrosinase Inhibitory Properties. Lipids. 2001 Dec;36(12):1321-6.
    [参考文献]: Aleksander Salwiński, Et Al. The Use Of Enzyme-Coupled Magnetic Nanoparticles For Studying The Spectra Of Unusual Substrates Of Mushroom Tyrosinase By Direct Surface-Assisted Laser Desorption/ionisation And High-Resolution Electrospray Ionisation Quadrupole-Quadrupole-Time-Of-Flight Mass Spectrometry. Rapid Commun Mass Spectrom. 2014 Sep 30;28(18):1957-63.
    [参考文献]: B Morin, Et Al. The Protein Oxidation Product 3,4-Dihydroxyphenylalanine (Dopa) Mediates Oxidative Dna Damage. Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1059-67.
    [参考文献]: Kathryn Newton, Et Al. Phenoloxidase And Qx Disease Resistance In Sydney Rock Oysters (Saccostrea Glomerata). Dev Comp Immunol. 2004 May 17;28(6):565-9.

    合成参考文献


    参考文献:10.1002/adma.201102677
    摘要:Nakatsuka MA, Hsu MJ, Esener SC, Cha JN, Goodwin AP. DNA‐Coated Microbubbles with Biochemically Tunable Ultrasound Contrast Activity. Advanced Materials. 2011 Sep 28;23(42):4908–12. doi: 10.1002/adma.201102677.
    参考文献:10.1007/s11356-016-6116-4
    摘要:Felczak A, Bernat P, Różalska S, Lisowska K. Quinoline biodegradation by filamentous fungus Cunninghamella elegans and adaptive modifications of the fungal membrane composition. Environmental Science and Pollution Research. 2016 Jan 26;23(9):8872–80. doi: 10.1007/s11356-016-6116-4.
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