2-Phenylsulphonylglutaronitrile置于0.1 M Et4Bf4体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.0H,以44%的收率获得产物戊二腈 参考文献:Bellamy,Anthony J.; Kerr,John B.; Mcgregor,Cchristopher J.,Journal Of The Chemical Society. Perkin Transactions Ii,1982,P. 161-168 标题:Bellamy,Anthony J.; Kerr,John B.; Mcgregor,Cchristopher J.,Journal Of The Chemical Society. Perkin Transactions Ii,1982,P. 161-168
专利号:US-8084569-B2 优先权日:2006-12-21 标 题 :Process for the synthesis of diaminopyridines from glutarimidines 发明人:MINTER AARON; STOKES BERLIN 权利人:MINTER AARON; STOKES BERLIN; DU PONT 摘要:A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
专利号:US-8022167-B2 优先权日:2006-12-21 标 题 :Process for the synthesis of diaminopyridines from glutaronitriles 发明人:MINTER AARON; STOKES BERLIN 权利人:MINTER AARON; STOKES BERLIN 摘要:A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
专利号:US-7999057-B2 优先权日:2008-07-08 标 题:Gas-phase process for the synthesis of diaminopyridines from glutaronitriles 发明人:HUTCHENSON KEITH W; MINTER AARON; SUNSHINE GREGG 权利人:DU PONT 摘要:A gas-phase, continuous process is provided for the manufacture of 2,6-diaminopyridine and related compounds from glutaronitriles, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
专利号:US-2011301314-A1 优先权日:2008-12-18 标题:Continuous liquid-phase process for the synthesis of diaminopyridines from glutaronitriles 发明人:HUTCHENSON KEITH W; MINTER AARON 权利人:HUTCHENSON KEITH W; MINTER AARON; DU PONT 摘要:A liquid-phase, continuous process is provided for the manufacture of 2,6-diaminopyridine and related compounds from glutaronitriles, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.
专利号:US-4918222-A 优先权日:1984-07-27 标 题 :Process for synthesis of N-acetylglycine 发明人:LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L 权利人:TEXACO INC 摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.
专利号:US-6337393-B1 优先权日:1997-11-13 标 题:Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation 发明人:BRENNAN THOMAS M; FRAUENDORF ALBRECHT W 权利人:PROTOGENE LAB INC 摘要:A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding site which is functionalized with a reactive chemical moiety; and depositing a substantially controlled and minute volume of liquid reagent solution onto the support surface, and in contact with the binding site. The reagent solution includes reactants contained in at least one relatively high boiling point solvent, in contrast to standard organic solvents for such reagents. Application of a high boiling point solvent substantially reduces evaporation of the reagent solution in the open environment during synthesis on the solid support while enabling the maintenance of a substantially high reaction yield.
参考文献:10.1007/s00253-019-09915-8 摘要:Chen Z, Zhao J, Jiang S, Wei D. Recent research advancements on regioselective nitrilase: fundamental and applicative aspects. Applied Microbiology and Biotechnology. 2019 Jun 24;103(16):6393–405. doi: 10.1007/s00253-019-09915-8.