CAS: 536-43-6; 1-(4-Butoxyphenyl)-3-(Piperidin-1-yl)Propan-1-One Hydrochloride

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CAS号50-00-0 甲醛 | CAS号6091-44-7 哌啶盐酸盐 | CAS号5736-89-0 4-(正丁氧基)苯乙酮

1-(4-Butoxyphenyl)-3-(1-Piperidinyl)-1-Propanol Hydrochloride置于双氧水体系中,用 乙醇 作为反应溶剂,以95.5 %的收率获得产物盐酸达克罗宁
参考文献:一种盐酸达克罗宁的合成方法
标题:一种盐酸达克罗宁的合成方法
摘要:本发明涉及药物合成技术领域,特别是涉及一种盐酸达克罗宁的合成方法.本发明所述的盐酸达克罗宁的合成方法是以对羟基苯甲醛和1‑溴丁烷为起始原料,在碱性催化剂条件下经过醚化反应得到4‑丁氧基苯甲醛;n‑(2氯乙基)哌啶与镁屑发生格氏反应,再与4‑丁氧基苯甲醛发生加成反应,然后在氯化铵条件下水解,再与盐酸乙醇成盐制备得到1‑(4‑丁氧基苯基)‑3‑(1‑哌啶基)1‑丙醇盐酸盐,最后经过双氧水氧化得到盐酸达克罗宁粗品,制备的盐酸达克罗宁粗品的收率达50%以上,纯度达99.0%以上;粗品在纯净水中进行重结晶得到盐酸达克罗宁,纯度可达99.9%以上.

专利信息

专利号:US-2007203079-A1
优先权日:2005-11-21
标题:Methods of using small molecule compounds for neuroprotection
发明人：CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.