📜2,2-Dimethyl-3-Dimethylaminopropanaloxim置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,化学反应生成 N,N,2,2-四甲基-1,3-丙二胺 参考文献:Synthesis Of Some Cis-And Trans-2-Dimethylaminomethyl Cyclic Amines And Related Diamines 标题:Synthesis Of Some Cis-And Trans-2-Dimethylaminomethyl Cyclic Amines And Related Diamines 摘要: DOI:10.1021/jo00891A005
专利号:WO-0140193-A1 优先权日:1999-12-03 标题:Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.
专利号:US-2002103381-A1 优先权日:2000-11-30 标 题 :Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-8178672-B2 优先权日:2004-10-19 标 题:Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase 发明人:ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC 权利人:ASHWELL MARK A; TANDON MANISH; LAPIERRE JEAN-MARC; ARQULE INC 摘要:An efficient route for the synthesis is of formula (I) of imidazooxazole and imidazothiazole inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions including inflammation and auto-immune responses is described.
专利号:US-5211935-A 优先权日:1991-10-04 标题 :Synthesis of crystalline mordenite-type material 发明人:CHANG CLARENCE D; HELLRING STUART D; STRIEBEL RANDY F 权利人:MOBIL OIL CORP 摘要:This invention relates to a new form of crystalline material identified as mordenite-type, to a new and useful method for synthesizing said crystalline material and to use of said crystalline material prepared in accordance herewith as a catalyst for organic compound, e.g. hydrocarbon compound, conversion.
专利号:US-5219547-A 优先权日:1991-10-04 标题 :Synthesis of crystalline mordenite-type material 发明人:HELLRING STUART D; STRIEBEL RANDY F 权利人:MOBIL OIL CORP 摘要:This invention relates to a new form of crystalline material identified as mordenite-type, to a new and useful method for synthesizing said crystalline material and to use of said crystalline material prepared in accordance herewith as a catalyst for organic compound, e.g. hydrocarbon compound, conversion.
参考文献:10.1055/s-0028-1087970 摘要:Park J, Ryu I, Park J, Ha D, Gong Y. Parallel Synthesis of Drug-like 5-Amino-Substituted 1,2,4-Thiadiazole Libraries Using Cyclization Reactions of a Carboxamidine Dithiocarbamate Linker. Synthesis. 2009 Feb 24;2009(06):913–20. doi: 10.1055/s-0028-1087970.